Ngwaahịa

C6 dicarboxylic acid, adipic acid, bụ kemịkalụ ikpo okwu dị mkpa na ụlọ ọrụ.Mmepụta adipic acid nke biobased bụ ihe ọzọ na-ekwe nkwa na ụzọ petrochemical dị ugbu a.N'ebe a, anyị na-akọ biosynthesis nke adipic acid site n'iji ụzọ aka aka arụ ọrụ sitere na ngbanwe nke beta-oxidation nke acid dicarboxylic.Ụzọ biosynthetic gụnyere condensation nke acetyl-CoA na succinyl-CoA iji mepụta ọkpụkpụ azụ C6 na mbelata na-esote, akpịrị ịkpọ nkụ, hydrogenation, na ntọhapụ nke adipic acid site na thioester ya.Ebu ụzọ nwale ụzọ ahụ na vitro site na iji enzymes ụzọ emegharịrị wee weba ya n'ọrụ n'ime Escherichia coli maka biosynthesis na mpụta nke adipic acid n'ime usoro omenala.A na-abawanye titer mmepụta site na ihe dịka okpukpu 20 site na nchikota nke iwere enzymes nke dabara adaba iji kpalite mmeghachi omume sịntetik yana ịba ụba nke ihe nkpuchi.Ọrụ a na-egosipụta biosynthesis kpọmkwem nke adipic acid site n'ụzọ sịntetik na-abụghị nke okike, nke nwere ike ime ka mmepụta ya dị ọhụrụ.