Phosphatase, alkaline CAS: 9001-78-9 ọcha, isi awọ ọcha ma ọ bụ peach monoclinic crystal ma ọ bụ ntụ ntụ.
| Nọmba katalọgụ | XD90379 |
| Aha ngwaahịa | Phosphatase, alkaline |
| CAS | 9001-78-9 |
| Usoro ihe omimi | C21H36N8O6 |
| Ibu molekụla | 496.57 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
| Koodu tarifu akwadoro | 35079090 |
Nkọwapụta ngwaahịa
| Nyocha | 99% |
| Ọdịdị | ọcha, isi awọ ọcha ma ọ bụ peach monoclinic crystal ma ọ bụ ntụ ntụ |
Ọ bụ ezie na a maara fluoride na-akpali ọkpụkpụ ọkpụkpụ, a ghọtachaghị usoro ndị dị n'okpuru ya.Ọmụmụ ihe n'oge na-adịbeghị anya etinyewo ụzọ Wnt/β-catenin dị ka nnukwu ihe nrịbama na usoro ihe ọmụmụ ọkpụkpụ.Ọmụmụ ihe anyị gara aga gosipụtara ọrụ nwere ike ịbụ nke ụzọ Wnt canonical na nhazi ọkpụkpụ nke oke ndị nwere fluoride na-adịghị ala ala, mana usoro ahụ ka edoghị anya.Ọmụmụ ihe dị ugbu a kpebiri itinye aka na akara Wnt/β-catenin na ọdịiche osteoblastic kpatara fluoride.N'iji osteoblasts nke bụ isi, anyị gosipụtara na fluoride kwalitere mmụba nke osteoblasts na okwu alkaline phosphate (ALP) yana ọkwa mRNA nke akara ọdịiche ọkpụkpụ, gụnyere ụdị m collagen (COL1A1), ALP na osteonectin.Anyị gara n'ihu chọpụta fluoride na-ebute phosphorylations na serine 473 nke Akt na serine 9 nke glycogen synthase kinase-3β (GSK3β), nke butere GSK-3β mgbochi na mgbe e mesịrị nchịkọta nuklia nke β-catenin, dị ka e gosiri site Western blot na immunofluorescence analysis. .Ọzọkwa, fluoride kpalitekwara nkwupụta nke Wnt-ezubere iche mkpụrụ ndụ ihe nketa metụtara 2 (Runx2).N'ụzọ dị mkpa, mmetụta dị mma nke fluoride na ọrụ ALP na okwu mRNA nke COL1A1, ALP, osteonection na Runx2 kagburu DKK-1, onye na-egbochi Wnt/β-catenin receptor.Ejikọtara ọnụ, nchoputa ndị a na-egosi na fluoride na-akwalite ọdịiche osteoblastic site na Akt- na GSK-3β-based activation nke ụzọ akara Wnt/β-catenin na isi osteoblasts oke.Nchọpụta anyị na-enye nghọta ọhụrụ banyere usoro ọrụ nke fluoride na osteoblastogenesis.
