N, N'-Methylenebisacrylamide Cas: 110-26-9 98% ọcha ntụ ntụ
| Nọmba katalọgụ | XD90231 |
| Aha ngwaahịa | N, N'-Methylenebisacrylamide |
| CAS | 110-26-9 |
| Usoro ihe omimi | C7H10N2O2 |
| Ibu molekụla | 154.1665 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
| Koodu tarifu akwadoro | 29241900 |
Nkọwapụta ngwaahịa
| Nyocha | > 98% |
| Mmiri na-adịghị edozi | <0.5% |
| Ọdịdị | Ọcha ntụ ntụ |
| Inorganic sulfates | <0.5% |
| Maka iji nyocha naanị, ọ bụghị maka ojiji mmadụ | iji nyocha naanị, ọ bụghị maka mmadụ |
Ọrụ dị mkpa nke fibroblasts na-ejikọta tumor (TAF) na ọganihu ọrịa kansa pụtara ugbu a na ọrịa cancer akpa ume na-abụghị obere cell (NSCLC).Agbanyeghị, usoro ọgwụgwọ megide TAF nwere oke n'ihi enweghị nghọta na usoro subtype akọwapụtara nke na-akpata mkpokọta ha.N'ebe a, akụrụngwa (ya bụ, matrix rigidity) na akara mitogenic soluble nke na-eme ka mkpokọta TAF sitere na isi subtypes NSCLC: adenocarcinoma (ADC) na squamous cell carcinoma (SCC).Azụlitere fibroblasts na substrata mebere iji gosipụta isi ike nkịtị ma ọ bụ etuto dị na mkpokọta serum dị iche iche, a kọwakwara usoro nchịkwa dị oke mkpa.Na njikwa fibroblasts sitere na anụ ahụ na-adịghị njọ, matrix stiffening naanị na-abawanye mkpokọta fibroblast, yana mmetụta a na-arụ ọrụ na-achịkwa ma ọ bụ tụnyere nke ihe uto soluble ruo 0.5% serum.Ihe na-akpali akpali nke matrix rigidity bụ β1 integrin mechano-sensing site na FAK (pY397), ma jikọtara ya na ịrị elu posttranscriptionally na β1 integrin okwu.A na-ahụkwa sekit mechano-regulatory nke ikpeazụ na TAF mana n'ụdị ụdị-ụdị akọwapụtara, n'ihi na SCC-TAF gosipụtara FAK dị elu (pY397), okwu β1, na ERK1/2 (pT202/Y204) karịa ADC-TAFs.Ọzọkwa, isiike matriks butere nnukwu mkpokọta TAF na SCC-TAF (> 50%) ma e jiri ya tụnyere ADC-TAFs (10%-20%).N'ụzọ dị iche, SCC-TAF bụ nke a na-eme ka ọ ghara inwe mmetụta dị ukwuu na serum, ebe ADC-TAF zara nzaghachi na ntinye uche dị elu naanị.Nchọpụta ndị a na-enye ihe akaebe mbụ nke usoro nhazi subtype-kpọmkwem nke mkpokọta NSCLC-TAF.Ọzọkwa, data ndị a na-akwado na usoro ọgwụgwọ ndị na-achọ iweghachite nku ume nkịtị na / ma ọ bụ β1 integrin-based mechano regulation nwere ike ịdị irè megide SCC-TAFs, ebe igbochi stromal growth factor signing nwere ike ịdị irè megide ADC-TAFs. Ọmụmụ a na-ekpughe usoro dị iche iche n'okpuru. mmụkọ na-adịghị mma nke fibroblasts na-akwado tumor na ụdị abụọ nke ọrịa cancer akpa ume, nke ga-enyere aka ịmepụta usoro ọgwụgwọ ahaziri iche megide mkpụrụ ndụ ndị a.
