5-Sulfosalicylic acid dihydrate Cas: 5965-83-3 White na-acha ọcha kristal.
| Nọmba katalọgụ | XD90230 |
| Aha ngwaahịa | 5-Sulfosalicylic acid dihydrate |
| CAS | 5965-83-3 |
| Usoro ihe omimi | C7H10O8S |
| Ibu molekụla | 254.215 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 29182900 |
Nkọwapụta ngwaahịa
| Sulfate | 5.5% kacha |
| Mmiri | 22% kacha |
| Ọdịdị | kristal na-acha ọcha ruo na-acha ọcha |
| Mkpokọta acid | 99-104% |
| Nyocha | 99% |
A na-enyocha polycations dị ka ndị na-ebu ibu iji wepụta acid nucleic ọgwụgwọ.Polycations bụ inert nke ọgwụ na-enwekarị ọrụ nke ibuga ibu ọgwụgwọ.Ọmụmụ ihe ọmụmụ a na-akọ njikọ nke polycation nke na-eme onwe ya (DSS-BEN) dabere na ọgwụ analọg polyamine N (1), N (11) -bisethylnorspermine (BENSpm).Emebere polycation ahụ ka ọ rụọ ọrụ abụọ dị ka onye na-ebufe mkpụrụ ndụ ihe nketa yana ọgwụ na-ezubere maka metabolism polyamine dysregulated na ọrịa kansa.N'iji nchikota NMR na HPLC, anyị na-akwado na polycation nke na-eme onwe ya na-enweta mmebi intracellular n'ime ọgwụ nne na nna BENSpm.BENSpm a tọhapụrụ na-ebelata ọkwa cellular nke spermidine na spermine ma kwalite polyamine catabolic enzymes spermine / spermidine N (1) -acetyltransferase (SSAT) na spermine oxidase (SMO).The synthesized polycations na-etolite polyplexes na DNA ma na-akwado nnyefe nke ọma.N'iji ikike nke BENSpm mee ka mkpụrụ ndụ kansa mara mkpụrụ ndụ kansa na apoptos nke TNFa kpatara bụ, anyị na-egosi na DSS-BEN na-akwalite ọrụ igbu mmadụ nke usoro ọgwụgwọ TNFa.Nchọpụta a kọrọ na-akwado DSS-BEN dị ka usoro nnyefe ọrụ abụọ nke nwere ike ịnapụta mkpụrụ ndụ ọgwụgwọ ma melite nsonaazụ nke usoro ọgwụgwọ mkpụrụ ndụ n'ihi mmebi intracellular nke DSS-BEN na BENSpm na uru bara uru nke BENSpm na polyamine dysregulated. metabolism na ọrịa cancer.
