Ngwaahịa

Submillimolar mkpokọta nke cytotoxic bile acid (BAs) na-ebute ọnwụ cell site na apoptosis.N'aka nke ọzọ, e gosipụtara ọtụtụ cytoprotective BA iji gbochie apoptosis n'otu ebe ịta ahụhụ.N'agbanyeghị nke ahụ, usoro ndị BA na-ebute mmetụta ndị a na-emegiderịta onwe ha ka edoghị anya.Ezubere ọmụmụ a iji chọpụta ma cytotoxic na cytoprotective BA, na ntinye uche na-arụ ọrụ physiologically, nwere ike gbanwee njirimara biophysical nke membranes lipid, nwere ike ịtụgharị n'ime mgbanwe na ọnụ ụzọ apoptotic nke mkpụrụ ndụ.A tụlere njide nke BA na akpụkpọ ahụ site na mgbanwe dị iche iche nke fluorescence nke BAs ewepụtara kwesịrị ekwesị.Usoro ndị a nwere mmekọrịta dị elu na nsogbu mmiri dị elu karịa na ngalaba mmiri mmiri nwere cholesterol bara ụba nke enyere iwu.E gosikwara BA ndị na-edeghị aha ka ha nwere ebe dị elu mgbe ha na akpụkpọ ahụ na-emekọrịta ihe.Na mgbakwunye, mmekọrịta nke cytotoxic BAs na akpụkpọ ahụ butere mgbasawanye nke akpụkpọ ahụ, dị ka ewepụtara na data FRET.Ọzọkwa, e gosiri na cytotoxic BAs nwere ike ịkpaghasị nhazi nke akpụkpọ ahụ site na kọlestrọl na ntinye uche na-arụ ọrụ physiologically nke BA, mmetụta anaghị ejikọta ya na iwepụ cholesterol.N'aka nke ọzọ, cytoprotective bile acid enweghị mmetụta na akpụkpọ ahụ.E kwubiri na, n'ihi mmetụta ndị a na-ahụ anya na akpụkpọ ahụ siri ike, ọrụ apoptotic nke cytotoxic BA nwere ike jikọta ya na mgbanwe na nhazi akpụkpọ anụ plasma (dịka mgbanwe nke ngalaba lipid) ma ọ bụ na-abawanye na mitochondrial membrane affinity maka protein apoptotic.