Ngwaahịa

Ihe gbasara gburugburu ebe obibi, dị ka ihe mejupụtara macronutrient nke nri, nwere ike inwe mmetụta dị ukwuu n'ihe ize ndụ nke ọrịa shuga na ọrịa metabolic.N'ime ọmụmụ ihe ugbu a, anyị na-egosipụta otu otu, nri dị mfe - leucine - nwere ike gbanwee nguzogide insulin site n'ime ihe n'ọtụtụ anụ ahụ na n'ọtụtụ ọkwa nke metabolism.A na-etinye ụmụ oke na nri nkịtị ma ọ bụ nnukwu abụba (HFD).A mụbara leucine nri ugboro abụọ site na mgbakwunye na mmiri ọṅụṅụ.Achọpụtara mRNA, protein na profaịlụ metabolomic zuru oke na anụ ahụ na serum nwere mmetụta insulin, yana njikọ ya na mgbanwe nke glucose homeostasis na nrịbama insulin.Mgbe izu 8 gasịrị na HFD, ụmụ oke na-etolite oke ibu, imeju abụba abụba, mgbanwe mkpali na anụ ahụ adipose na nguzogide insulin na ọkwa nke IRS-1 phosphorylation, yana mgbanwe na profaịlụ metabolomic nke amino acid metabolites, TCA okirikiri intermediates, glucose na cholesterol metabolites. , na acid fatty na imeju, akwara, abụba na serum.Leucine iri abụọ na-eri nri mere ka ọtụtụ n'ime mmebi metabolite wee mee ka mmụba pụtara ìhè na nnabata glucose yana akara insulin na-agbanweghị oriri ma ọ bụ ibu ibu.A na-ejikọtakwa mmụba nke leucine nri na mbelata nke ịba ọcha n'anya steatosis na mbelata mbufụt na anụ ahụ adipose.Mgbanwe ndị a mere n'agbanyeghị mmụba nke phosphorylation nke insulin na-akpali akpali nke p70S6 kinase na-egosi mmụba nke mTOR, ihe omume na-ejikọta ya na nguzogide insulin.Ihe data ndị a na-egosi na mgbanwe dị nta na otu ihe gburugburu ebe obibi / ihe oriri nwere ike gbanwee ọtụtụ usoro metabolic na mgbaàmà ma gbanwee HFD na-ebute ọrịa metabolic site n'ime ihe n'ogo usoro na ọtụtụ anụ ahụ.Ihe data ndị a na-egosikwa na ịba ụba leucine nri nwere ike inye ihe mgbakwunye na njikwa nke nguzogide insulin metụtara oke ibu.