Ngwaahịa

Mmụba nke eucine-rich repeat kinase 2 (LRRK2) bụ ihe a kacha mara amara na-ebute ọrịa Parkinson (PD).Akụkụ ahụike nke LRRK2 PD enweghị ike ịmata ọdịiche dị na PD idiopathic, yana nchịkọta α-synuclein na / ma ọ bụ tau na / ma ọ bụ ubiquitin na nchịkọta intraneuronal.Nke a na-egosi na LRRK2 bụ isi ihe iji ghọta etiology nke nsogbu ahụ.Ọ bụ ezie na enweghị ọrụ adịghị ka ọ bụ usoro na-akpata PD na ndị ọrịa LRRK2, o doghị anya ka protein a si ebute nsí.N'ime ọmụmụ ihe a, anyị na-akọ na LRRK2 overexpression na sel na na vivo na-emebi ọrụ nke ụzọ ubiquitin-proteasome, na nke a na-akpata nchịkọta nke ụdị dị iche iche na LRRK2 overexpression.Anyị na-egosi na nke a abụghị onye ogbugbo site na nnukwu nchịkọta LRRK2 ma ọ bụ nhazi nke ubiquitin na nchịkọta.N'ụzọ dị mkpa, a naghị ahụ ihe na-adịghị mma dị otú ahụ site na nkwuwapụta nke protein LRRK1 yiri ya.Ihe omuma anyi na-egosi na LRRK2 na-egbochi mwepu nke proteasome substrate s elu nke proteasome catalytic ọrụ, na-akwado nchikota protein na nchikota nchikota.Ya mere, anyị na-enye njikọ molekụla n'etiti LRRK2, ihe kacha mara amara nke PD, na ụdị phenotype nke protein a kọwara na mbụ.