Ngwaahịa

Ịba ọcha n'anya nke ndị na-achọ ọgwụ bụ otu n'ime ihe na-echegbu onwe ya na nyocha ọgwụ na nchọpụta ọgwụ mbụ.Nchọpụta nke nrụgide oxidative imeju nwere ike ịbụ ihe ngosi mmalite nke hepatotoxicity yana uru nhọrọ ọgwụ.glutathione (GSH) na glutathione disulfide (GSSG), dị ka otu n'ime isi redox intracellular redox na-achịkwa ndị di na nwunye, na-arụ ọrụ dị mkpa n'ichebe mkpụrụ ndụ site na nrụgide oxidative nke na-akpata site na ahaghị nhata n'etiti prooxidants na antioxidants.Mkpebi ọnụọgụgụ nke oke GSSG/GSH na mkpokọta GSH na GSSG ka ejirila gosi nrụgide oxidative na sel na anụ ahụ.N'ime ọmụmụ ihe a, anyị nwalere ohere nke iji biliary GSSG/GSH ratios dị ka biomarker iji gosipụta nrụgide oxidative imeju na nsị ọgwụ.A nwalere ogige anọ a maara na-agbanwe ọkwa GSH na GSSG n'ime ọmụmụ ihe a.Diquat (diquat dibromide monohydrate) na acetaminophen ka enyere oke.A na-enye Paraquat na tert-butyl hydroperoxide maka ụmụ oke iji kpalite mgbanwe nke biliary GSH na GSSG.A na-atụle biliary GSH na GSSG site na iji usoro nhazi nhazi nke a kwadebere na bile artificial iji kọwaa mmetụta ọ bụla bile matrix na nyocha LC-MS na iji zere ndabichi nke GSH na GSSG endogenous.N'ihe atụ anọ (na oke na ụmụ oke) nke mgbanwe ọgwụ na-akpata na kinetics nke biliary GSSG/GSH ratios, ọmụmụ a gosipụtara ike ịmepụta ihe ngosi nzaghachi nke dabeere na biliary GSSG/GSH ratios maka ịkọ nrụgide oxidative hepatic.