Ngwaahịa

Nhazi Acyl-CoA na-ebute metabolism fatty acid cellular.A na-emepụta Acyl-CoA site na njikọ nke fatty acid na Coenzyme A nke ezinụlọ buru ibu nke acyl-CoA synthetases (ACS) na-elekọta.N'aka nke ọzọ, ezinụlọ nke acyl-CoA thioesterases (ACOT) nwere ike megharịa acyl-CoAs.N'ebe a, anyị ekpebiela ụkpụrụ ntụgharị nke ACS na ACOT enzymes n'ofe anụ ahụ yana nzaghachi na nsogbu metabolic.Anyị na-ahụ usoro nhazi ahaziri ahazi n'ime na n'etiti ezinaụlọ ndị a yana ụkpụrụ dị iche iche na-eme n'ụdị anụ ahụ na-adabere na physiologically.N'ihi mgbanwe a hụrụ na ogologo ogologo ACOT mRNA na protein dị ukwuu na imeju na anụ ahụ adipose, anyị kpebisiri ike ihe ga-esi na mmụba cytosolic ogologo thioesterase ọrụ na metabolism fatty acid na anụ ahụ ndị a site n'ịmepụta ụmụ oke transgenic na-egosipụta hyperactive mutant nke Acot7 na anụ ahụ. imeju ma ọ bụ anụ ahụ adipose.Ugboro abụọ cytosolic acyl-CoA thioesterase ọrụ echebeghị mic e site na oke ibu nke nri kpatara, imeju abụba ma ọ bụ nguzogide insulin, agbanyeghị, nkwuwa okwu nke Acot7 na adipocytes mere ka ụmụ oke ghara idi oyi.Ọnụ, data ndị a na-atụ aro ụdị usoro nhazi dị iche iche nke ACS na ACOT enzymes yana na enzymes ndị a na-arụ ọrụ n'ụdị ejikọtara ọnụ iji chịkwaa metabolism fatty acid n'ụzọ dabere na anụ ahụ.