Ngwaahịa

1.Ichoputa ma adenosine nke enwetara adenosine diphosphate (ADP) nwere ike igbochi nchịkọta platelet, karịsịa na ọnụnọ P2Y₁₁ antagonist, ebe a ga-egbochi mmetụta nke ADP na P2Y₁₂ receptor. A tụrụ nchịkọta Plalatelet na nzaghachi nke onye na-anabata thrombin. peptide site na ọnụ ọgụgụ platelet na plasma-bara ụba nke platelet (PRP) na ọbara dum n'ihu ADP na P2Y₁₂ antagonists cangrelor, prasugrel active metabolite, na ticagrelor.N'ebe onye mmegide P2Y₁₂, preincubation nke PRP na ADP gbochiri mkpokọta;Akwụsịla mmetụta a site na adenosine deaminase.Enweghị mgbochi nke mkpokọta mere n'ọbara dum ma e wezụga mgbe etinyere dipyridamole iji gbochie nnabata adenosine n'ime erythrocytes.A na-emegharị mmetụta nke ADP na PRP na ọbara dum site na iji adenosine ma na-ejikọta ya na mgbanwe na cAMP (nke a na-enyocha site na phosphoprotein phosphorylation vasodilator-stimulated).Nsonaazụ niile bụ otu n'agbanyeghị nke P2Y₁₁ ant agonist eji.ADP na-egbochi nchịkọta platelet n'ihu onye mmegide P2Y₁₂ site na ntụgharị gaa na adenosine.Mgbochi na-eme na PRP ma ọ bụghị n'ọbara dum ma e wezụga mgbe a na-egbochi adenosine.Ọ dịghị onye ọ bụla n'ime ndị na-emegide P2Y₁₁ ndị a mụrụ megharịrị mmetụta nke dipyridamole na nnwale ndị emere.

A na-ewere 2.ADP dị ka agonist platelet na-adịghị ike n'ihi nzaghachi nchịkọta dị ntakịrị ọ na-eme ka in vitro na nchịkọta physiological nke extracellular Ca (2+) [(Ca (2+)) (o) ].Ibelata [Ca(2+)] (o) na-eme ka mkpokọta ADP kpalitere n'ụzọ na-emegide onwe ya, mmetụta nke ekwuru na mmepụta thromboxane A(2) kwalitere.Ọmụmụ ihe a nyochara ọrụ nke ectonucleotidases na [Ca (2+)] (o) -dabere nke ịgbalite platelet.Mbelata [Ca(2+)] (o) site na millimolar gaa na ọkwa micromolar tụgharịrị ADP (10 μmol/l) - mkpokọta platelet ewepụtara site na nke na-agafe agafe gaa na nzaghachi na-adịgide adịgide na plasma abụọ nwere ụbara platelet na nkwusioru sachaa.Na-egbochi mmepụta thromboxane A (2) na aspirin enweghị mmetụta na nke a [Ca (2+)] (o) -dabere.Mgbochi nke mmebi ADP kpochapụrụ ọdịiche dị n'etiti ala na physiological [Ca (2+)] (o) na-eme ka nchịkọta siri ike ma na-adịgide adịgide na ọnọdụ abụọ ahụ.Ntụle nke extracellular ADP kpughere mbelata mbelata na plasma na apyrase-containin g saline na micromolar ma e jiri ya tụnyere millimolar [Ca(2+)] (o).Dị ka a kọrọ na mbụ, thromboxane A (2) ọgbọ na-eme ka ọ dịkwuo ala [Ca (2+)] (o) , Otú ọ dị nke a na-adabere na ọrụ ectonucleotidase (.) P2Y antagonists antagonists cangrelor na MRS2179 gosipụtara mkpa P2Y (12) ndị na-anabata ya. maka mkpokọta ADP kpalitere na-adịgide adịgide, yana obere ọrụ maka P2Y(1).N'ikpeazụ, Ca (2+) -dependent ectonucleotidase ọrụ bụ isi ihe na-ekpebi oke nchịkọta platelet na ADP na a ga-achịkwa ya maka ọmụmụ ihe na-arụ ọrụ P2Y.