Ngwaahịa

Iji nyochaa mmetụta nke spearmint mmanụ na emphysema-dị ka mgbanwe na okwu nke tumor necrosis factor-alpha (TNF-alpha), interleukin-1beta (IL-1beta), matrix metalloproteinase-9 (MMP-9) na anụ ahụ inhibitor nke metalloproteinase. -1 (TIMP-9) na lipopolysaccharide (LPS) na-agwọ oke oke.Emphysematous mgbanwe nlereanya na-akpali site intracheal instillation nke LPS otu ugboro n'izu maka ruo 8 izu na oke.E kewara oke n'ime njikwa, dexamethasone (0.3 mg x kg(-1)), na mmanụ spearmint (10, 30,100 mg x kg(-1)) otu.A na-eji saline, dexamethasone na spearmint mmanụ agwọ otu ọ bụla maka izu anọ.Mgbe ahụ, a na-eme ngụkọta ọnụ ọgụgụ sel ọcha dị iche iche na bronchoalveolar lavage fluid(BALF).Mgbanwe pathologic nke anụ ahụ ngụgụ dị ka usoro alveolar, mbufụt nke ikuku, na metaplasia cell goblet bụ nke HE na AB-PAS na-enweta.A tụrụ nkwupụta nke TNF-alpha, IL-1beta, TIMP-1 na MMP-9. Ma spearmint na dexamethasone belatara mbibi nke alveolus pulmonary.Ngụkọta ọnụ na ọnụ ọgụgụ ọbara ọcha dị iche iche na BALF gụnyere neutrophile na lymphocyte nke mmanụ spearmint 100 mg x kg(-1) na otu dexamethasone belatara nke ukwuu, ma gbochie metaplasia cell goblet.Dexamethasone nwere mmetụta mgbochi na nkwupụta nke TNF-alpha, IL-1beta, TIMP-1 na MMP-9.Mmanụ Spearmint 30, 100 mg x kg(-1) belatara nke ukwuu TNF-alpha na IL-1beta n'otu n'otu.Mmanụ spearmint 10, 30 na 100 mg x kg (-1) enweghị mmetụta na nkwupụta TIMP-1, mana ọ nwere ike ibelata okwu MMP-9 nke ukwuu na anụ ahụ ngụgụ. ebe ọ na-eme ka mbibi alveolar dịkwuo mma, mbufụt nke akpa ume, na metaplasia cell goblet.Usoro ahụ nwere ike ịgụnye ibelata ọdịnaya TNF-alpha, IL-1beta na igbochi oke ngosipụta nke matrix metalloproteinase-9 na anụ ahụ ngụgụ.