Spiramycin Cas: 8025-81-8
| Nọmba katalọgụ | XD90452 |
| Aha ngwaahịa | Spiramycin |
| CAS | 8025-81-8 |
| Usoro ihe omimi | C43H74N2O14 |
| Ibu molekụla | 843.05 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
| Koodu tarifu akwadoro | 29419000 |
Nkọwapụta ngwaahịa
| Ọdịdị | Ọcha ntụ ntụ |
| Nyocha | > 4100IU / mg |
| Ọla dị arọ | <20pm |
| Ọnwụ na ihicha | <3.5% |
| Sulfated Ash | <1.0% |
| Ethanol | <2.0% |
| Ntụgharị anya pụrụ iche | -85 ruo -80 |
Streptomyces ambofaciens na-emepụta macrolide ọgwụ nje spiramycin.Achọpụtala ụyọkọ mkpụrụ ndụ ihe nketa biosynthetic maka spiramycin maka S. ambofaciens.Na mgbakwunye na usoro nhazi usoro srmR (srm22), nke achọpụtara na mbụ (M. Geistlich et al., Mol. Microbiol. 6:2019-2029, 1992), mkpụrụ ndụ ihe nketa na-edozi ihe atọ achọpụtala site na nyocha usoro.Nyocha okwu mkpụrụ ndụ ihe nketa na nnwale inactivation nke mkpụrụ ndụ ihe nketa gosiri na ọ bụ naanị otu n'ime mkpụrụ ndụ ihe nketa atọ a, srm40, na-ekere òkè dị ukwuu na nhazi nke biosynthesis spiramycin.Nkwụsị nke srm22 ma ọ bụ srm40 wepụrụ mmepụta spiramycin ebe oke okwu ha na-abawanye mmepụta spiramycin.Emere nyocha nkwupụta site na ntụgharị ntụgharị-PCR (RT-PCR) maka mkpụrụ ndụ ihe nketa niile nke ụyọkọ n'ụdị anụ ọhịa yana na srm22 (srmR) na srm40 mutant nhichapụ.Nsonaazụ sitere na nyocha okwu, yana ndị sitere na nnwale mmeju, gosiri na achọrọ Srm22 maka okwu srm40, Srm40 bụ onye na-arụ ọrụ akọwapụtara nke ọma na-achịkwa ọtụtụ, ma ọ bụrụ na ọ bụghị ha niile, nke mkpụrụ ndụ ihe nketa biosynthetic spiramycin.
