Polymyxin B sulfate CAS: 1405-20-5 ntụ ntụ ọcha
| Nọmba katalọgụ | XD90360 |
| Aha ngwaahịa | Polymyxin B sulfate |
| CAS | 1405-20-5 |
| Usoro ihe omimi | C55H96N16O13 · 2H2SO4 |
| Ibu molekụla | 1385.61 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
| Koodu tarifu akwadoro | 29419000 |
Nkọwapụta ngwaahịa
| Mmechi | Dabara na USP35 |
| Ọla dị arọ | <20ppm |
| pH | 5-7 |
| njirimara | Liquid chromatography: kwekọrọ |
| Nyocha | 99% |
| Ọdịdị | Ọcha ntụ ntụ |
| Ọnwụ na ihicha | <6% |
| Solubility | Na-agbaze kpamkpam n'ime mmiri, soluble ntakịrị na Ethanol |
| Sulfate | 15.5% - 17.5% |
| Nha urughuru | <30µm |
| Ntụgharị anya pụrụ iche | -78°-90° |
| Phenylalanine | 9.0% -12.0% |
| Pyrogens | Na-emezu ihe achọrọ |
| Sulfated ntụ | <0.75% |
| Mgbakọta ọnụ ikuku ikuku nwere ike ime | <100cfu/g |
| Ike | > 6500 IU / mg |
The ExPortal protein secretion organelle na Streptococcus pyogenes bụ anionic phospholipid nwere membrane microdomain emejupụtara na Sec translocons na postsecretion protein biogenesis ihe.Polymyxin B na-ejikọta ma na-akpaghasị iguzosi ike n'ezi ihe nke ExPortal, na-ebute nzuzo nzuzo nke ọtụtụ nsị.Iji nweta nghọta n'ime ihe ndị na-emetụta nzukọ ExPortal, a na-eduzi ihuenyo mkpụrụ ndụ ihe nketa ịhọrọ maka ụmụ anụmanụ na-eguzogide polymyxin B na-egosipụta iguzosi ike n'ezi ihe ExPortal.Nhazi nke genome zuru oke nke mutant 25 na-eguzogide, ekpughere site na mmụgharị otu ruo anọ n'otu mkpụrụ ndụ mkpụrụ ndụ mutant gbakọtara nke ọma n'ime otu mkpụrụ ndụ ihe nketa iri.Mwube nke mutant nwere nhichapụ ma ọ bụ ntinye n'otu n'otu gosipụtara na 7 isi mkpụrụ ndụ ihe nketa na-enye nguzogide na nkwalite iguzosi ike n'ezi ihe ExPortal site na enweghị ọrụ, ebe 3 nwere ike ịbụ n'ihi inweta ọrụ yana/ma ọ bụ mmetụta njikọta.Mkpụrụ ndụ ihe nketa na-eguzogide isi na-agụnye onye na-ahazi transcriptional nke lipid biosynthesis, ọtụtụ mkpụrụ ndụ ihe nketa na-etinye aka n'inweta nri na-edozi ahụ, na ụdị mkpụrụ ndụ dị iche iche na-etinye aka na nzaghachi nrụgide.Ndị otu abụọ nọ na klaasị ikpeazụ na-arụkwa ọrụ dị ka ndị na-ahazi akwụkwọ akụkọ nke speB cysteine protease zoro ezo.Nyocha nke mmụgharị dịpụrụ adịpụ na-adịkarị, otu mkpochapụ nucleotide n'ime egwu nke 9 adenine residues na pstS, na-edobe akụkụ nke ihe na-ebugharị Pi na-enwe mmekọrịta dị elu, na-atụ aro na usoro a na-arụ ọrụ dị ka mgbanwe molekụla iji kwado mgbanwe nrụgide.Ọnụ, data ndị a na-egosi ịdị adị nke nzaghachi nrụgide akpụkpọ ahụ nke na-akwalite iguzosi ike n'ezi ihe ExPortal na iguzogide peptides antimicrobial cationic.
