N- (2-Acetamide) iminodiacetic acid Cas: 26239-55-4 99% White ntụ ntụ.
| Nọmba katalọgụ | XD90194 |
| Aha ngwaahịa | ADA (N-(-2-Acetamido)iminodiacetic acid) |
| CAS | 26239-55-4 |
| Usoro ihe omimi | C6H10N2O5 |
| Ibu molekụla | 190.15 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 29241900 |
Nkọwapụta ngwaahịa
| Fe | <5ppm |
| Pb | <5ppm |
| Ọnwụ na ihicha | <0.5% |
| Sulfated ntụ | <0.1% |
| Ọdịdị | Ọcha ntụ ntụ |
| Ihe mgbaze ndị ọzọ | Ọ dịghị |
| Oge mgbasa (9g na 91ml 1M NaOH, mkpali magnetik) | <1 nkeji |
| A300 (9% na 1 M NaOH) | <0.08% |
| Ọnụọgụ nke njedebe achọpụtara n'usoro titration | Abụọ naanị |
| Oke pH nke na-akọwa njedebe njedebe nke abụọ | 9.1-10.1 |
| Solubility (9% na 1M NaOH) | Dị ọcha na enweghị agba |
| Ụbọchị nrụpụta | |
| Mmiri KF | <1% |
| Assay (Titration) na ntọala a mịrị amị | > 99.0% |
| Infrared | Na-akwado |
Nucleoside adenosine na-arụ ọrụ na ụjọ na usoro obi site na onye na-anabata A2A (A2AR).Na nzaghachi na ọkwa oxygen dị na anụ ahụ, a na-ahazi ntinye plasma adenosine karịsịa site na njikọ ya site na CD73 yana site na mmebi ya site na adenosine deaminase (ADA).Endopeptidase CD26 nke dị n'elu cell na-achịkwa ntinye nke peptides vasoactive na antioxidant ma na-achịkwa ikuku oxygen na anụ ahụ na nzaghachi nrụgide oxidative.Ọ bụ ezie na a na-edepụta oke nke adenosine, CD73, ADA, A2AR, na CD26 na nzaghachi hypoxia, mmetụta nke hyperoxic na hyperbaric ọnọdụ na ihe ndị a kwesịrị nlebara anya ọzọ.Oke na ahịrị cell murine Chem-3 nke na-egosipụta A2AR ka ekpughere na 0.21 bar O2, 0.79 bar N2 (ọnọdụ ụwa; normoxia);1 mmanya O2 (hyperoxia);2 mmanya O2 (hyperbaric hyperoxia);0.21 mmanya O2, 1.79 mmanya N2 (hyperbaria).Adenosine plasma ntinye uche, CD73, ADA, A2AR okwu, na CD26 ọrụ e kwuru okwu na vivo, na cAMP mmepụta e kwuru na cellulo.N'ihi na ọnọdụ vivo, 1) hyperoxia belatara adenosine plasma larịị na T cell elu CD26 ọrụ, ebe ọ na-amụba CD73 okwu na ADA larịị;2) hyperbaric hyperoxia na-eme ka usoro ahụ dịkwuo elu;na 3) hyperbaria naanị enweghị mmetụta dị ukwuu na paramita ndị a.Na ụbụrụ na cellulo, 1) hyperoxia belatara okwu A2AR;2) hyperbaric hyperoxia kwalitere omume;na 3) hyperbaria naanị gosipụtara mmetụta kachasị ike.Anyị chọtara ụkpụrụ yiri nke ahụ gbasara njikọ A2AR mRNA na ụbụrụ yana mmepụta cAMP na sel Chem-3.Ya mere, ọkwa oxygen dị elu na-achọ imebi ụzọ adenosinergic na ọrụ CD26.Hyperbaria naanị metụtara naanị okwu A2AR na mmepụta cAMP.Anyị na-atụle ka usoro ndị dị otú ahụ na-akpalite hyperoxygenation nwere ike igbochi, site na vasoconstriction, ikuku oxygen na-enye anụ ahụ na mmepụta nke ụdị oxygen na-emeghachi omume.
