Ngwaahịa

Ornithine aspartate bụ nke mbụ a na-eji ụlọ ọgwụ eme ihe n'ịgwọ ọrịa afọ ntachi na ọrịa imeju.Na mkpokọta nke ahụike ngwa ahụmahụ, ornithine aspartate ka ọtụtụ ebe na-eji na ọgwụgwọ nke ọrịa imeju, na enwetawo kpọmkwem curative mmetụta na hepatic encephalopathy, ọgwụ-akpata imeju mmebi, ọdụdụ imeju, ala ala ịba ọcha n'anya na ọrịa ndị ọzọ, e n'ọtụtụ ebe. ghọtara site na ụlọ ọgwụ.

Ornithine aspartate na-enye mkpụrụ maka urea na njikọ glutamine na vivo.Glutamine bụ ngwaahịa detoxification nke amonia, yana ụdị nchekwa na njem nke amonia.N'okpuru ọnọdụ physiological na pathological, njikọ nke urea na njikọ nke glutamine na-emetụta ornithine, aspartic acid na ogige dicarboxyl ndị ọzọ.Ornithine na-etinye aka na ihe fọrọ nke nta ka ọ bụrụ usoro niile nke ịgbalite usoro urea na detoxification nke amonia.A na-emepụta arginine n'oge usoro a, a na-ekewa urea ka ọ bụrụ ornithine.Aspartic acid na-ekere òkè na njikọ nke nucleic acid na hepatocytes iji kwado mmezi nke hepatocytes mebiri emebi.Na mgbakwunye, n'ihi nkwalite na-apụtaghị ìhè nke aspartic acid na usoro metabolic nke tricarboxylic acid okirikiri na sel imeju, ọ na-akwalite njikọ ike na sel imeju, nke na-enyere aka nrụzi mkpụrụ ndụ imeju mebiri emebi ma na-eme ka mgbake nke ọrụ imeju dịkwuo elu.Ọganihu na-adịbeghị anya egosila na aspartate nwekwara ike igbochi ọrụ nke inflammasomes site na ndị na-anabata N-methyl-D-aspartate (NMDA), si otú ahụ na-ebelata usoro ọgwụ nke mmeghachi omume mkpali imeju.Ndị na-anabata NMDA bụ ụdị subtype nke ionotropic excitatory glutamate receptors, nke na-arụ ọrụ dị mkpa na usoro physiological dị ka nnyefe synaptic, synaptic plasticity, mmụta na ebe nchekwa na usoro nhụjuanya nke etiti.Ọmụmụ pathological sochirinụ gosikwara na aspartate na-emeziwanye ọnya na-egbu egbu na imeju.

Ngwa ụlọ ọgwụ

N'ihe gbasara ọrịa imeju: Ornithine aspartate na-ejikarị eme ihe dị ka ọgwụ mgbochi mkpali na hepatoprotective na ọgwụgwọ nke ọrịa imeju dị iche iche, dị ka ọrịa imeju imeju, mmebi imeju nke ọgwụ na-akpata, imeju abụba abụba, ịba ọcha n'anya na-adịghị ala ala, wdg. amonia ọbara n'ime ndị ọrịa nwere ọrịa encephalopathy na enyemaka nke mgbaàmà neuropsychiatric na-eji nwayọọ nwayọọ na-aghọ ọgwụ bụ isi ọgwụgwọ maka ọgwụgwọ ọrịa imeju dị iche iche.

Ornithine aspartate bụ ihe dị mkpa maka njikọ nke urea na glutamine.Ornithine nwere ike ịgbalite enzymes isi na usoro nke urea njikọ - ornithine carbamoyltransferase na carbamoyl phosphate synthase, na-akwalite amonia Metabolism iji nweta detoxification nke ọbara amonia, aspartic acid dị ka mkpụrụ nwere ike ịmepụta glutamic acid na oxaloacetic acid, glutamine bụ ngwaahịa detoxification. amonia, na ọ bụkwa nchekwa na njem nke amonia.Oxaloacetate na-ekere òkè na usoro tricarboxylic acid, na-akwalite mmepụta ume n'ime mkpụrụ ndụ imeju, ma na-eme ka mkpụrụ ndụ imeju mebiri emebi gbanwee, megharịa, na iweghachi ọrụ imeju.Ornithine aspartate nwere ike imeziwanye ọrụ imeju nke ọma, belata amonia ọbara, na synergistically belata amonia na lactulose na ofloxacin, si otú a na-emeziwanye ọgwụgwọ nke encephalopathy imeju nke ọma, nke kwesịrị maka ngwa ụlọ ọgwụ.

Oncology: Site na mgbanwe na-aga n'ihu na ụdị na doses nke ọgwụ chemotherapy, nsogbu ndị metụtara ọgwụ chemotherapy na-apụtakwa, mmebi imeju bụ otu n'ime mmebi akụkụ ahụ na-emekarị.Ozugbo mmebi imeju na-eme, ọ ga-emetụta ahụike anụ ahụ na nke uche nke ndị ọrịa n'ogo dịgasị iche iche, na-egbochi mmejuputa usoro ọgwụgwọ chemotherapy, na-ebelata mmetụta ọgwụgwọ nke chemotherapy.N'ọnọdụ ndị siri ike, ọdịda imeju nwere ike ịdị ize ndụ.Ornithine aspartate nwere ike imeziwanye mmebi imeju nke ọgwụ chemotherapy kpatara ma melite mmetụta ọgwụgwọ nke ndị ọrịa etuto ahụ.

Ebe ịwa ahụ: Ịwa ahụ bụ ihe na-egbu anụ ahụ dum nke onye ọrịa, na mmebi imeju na-arụ ọrụ imeju bụkwa ihe mgbagwoju anya.Ornithine aspartate nwere ike igbochi ma na-agwọ mmebi imeju na-arụ ọrụ ma kwalite mgbake nke ndị ọrịa.