Ngwaahịa

A na-eche na fibrosis pulmonary Idiopathic gụnyere mmerụ ahụ nku ume nke ụdị oxygen na-emeghachi omume (ROS), nke n'aka nke ya na-esote fibrosis na-adịghị mma.Ihe na-agbanwe agbanwe (TGF) -β1 na-ebute mmụba na ọnụọgụ myofibroblast na-arụ ọrụ dị mkpa na fibrosis a na-adịghị mma.N'oge na-adịbeghị anya, anyị chọpụtara na mepenzolate bromide (mepenzolate), nke ejirila ụlọ ọgwụ na-agwọ ọrịa eriri afọ, nwere ihe ndị na-ebelata ROS.N'ime ọmụmụ ihe ugbu a, anyị nyochara mmetụta nke mepenzolate na bleomycin na-ebute fibrosis pulmonary na ngụgụ na-arụ ọrụ na ụmụ oke.Achọpụtara ịdị njọ nke fibrosis nke akpa ume site na nyocha histopathologic na mkpebi nke ọkwa hydroxyproline.A na-enyocha usoro nku ume (elastance) na ọrụ iku ume [ikike dị mkpa (FVC)] site na iji igwe ikuku na-achịkwa kọmputa.A tụlekwara ọrụ iku ume site na nyochaa saturation oxygen saturation percutaneous (SpO2).Nlekọta intracheal nke mepenzolate tupu ọgwụgwọ bleomycin belatara oke fibrosis pulmonary na mgbanwe na igwe ngụgụ ma mee ka mgbake dị ukwuu nke FVC na SpO2 ma e jiri ya tụnyere njikwa.Ọzọkwa, mepenzolate mepụtara mmetụta ọgwụgwọ ọbụna mgbe a na-enye ya mgbe mmepe nke fibrosis gasịrị.Nlekọta nke mepenzolate egbochikwara bleomycin na-akpata ọnwụ pulmonary cell na nzaghachi mkpali na ụbara ọnụ ọgụgụ myofibroblast.Mepenzolate belatara ọrụ NADPH oxidase yana ọkwa TGF-β1 na-arụ ọrụ ma ọ bụ mmụba glutathione S-transferase (GST) na ọnụnọ ọgwụgwọ bleomycin.Nsonaazụ ndị a na-egosi na nchịkwa intratracheal nke mepenzolate belatara bleomycin na-ebute fibrosis pulmonary na ngụgụ na-arụ ọrụ na ụmụ oke.Mmetụta ndị a nwere ike ịbụ n'ihi mmetụta mgbochi ọgwụ a na NADPH oxidase na ọrụ TGF-β1 yana mmetụta mkpali ya na GST.