D-Valine Cas: 640-68-6 C5H11NO2
| Nọmba katalọgụ | XD90291 |
| Aha ngwaahịa | D-Valine |
| CAS | 640-68-6 |
| Usoro ihe omimi | C5H11NO2 |
| Ibu molekụla | 117.14634 |
| Nkọwa nchekwa | Okpomọkụ ụlọ |
| Koodu tarifu akwadoro | 29224995 |
Nkọwapụta ngwaahịa
| Nyocha | 99% |
| Ọdịdị | Ọcha ntụ ntụ |
| Njupụta | 1.2000 (atụmatụ) |
| Ebe mgbaze | >295 Celsius C (sbl.) (ọkụ) |
| Ebe esi nri | 213.6 Celsius C na 760 mmHg |
| ebe mgbari | 83 ℃ |
| Ntụgharị ntụgharị | -27 Celsius (C=8, 6mol/L HCl) |
| Solubility | 56 g/L (20°C) |
| Mmiri solubility | 56 g/L (20ºC) |
| PSA | 63.32000 |
| LogP | 0,75460 |
| Ntughari pụrụ iche | -27.5º (c=5, 5N HCl) |
| Ọrụ anya | [α] 23/D -32.0 ruo -24.0°, c = 8 na 6 M HCl |
Ụmụ nwanyị nwere ọrịa antiphospholipid (APS) nọ n'ihe ize ndụ dị ukwuu nke ọnwụ ime ime ugboro ugboro (RPL) na preeclampsia.Antiphospholipid antibodies (aPL) na-agbanwe ọrụ trophoblast ozugbo.Ọgwụgwọ na heparin dị arọ dị ala (LMWH) na-ebelata ohere nke RPL mana ọ bụghị preeclampsia.Ọzọkwa, LMWH na-akpali ntọhapụ trophoblast sFlt-1, ihe mgbochi angiogenic metụtara preeclampsia.Ebe ọ bụ na enweghi vitamin D jikọtara ya na APS na preeclampsia, nchọpụta a chọrọ iji chọpụta mmetụta vitamin D na ọrụ trophoblast na nhazi nke aPL na LMWH.A mmadụ mbụ trimester trophoblast cell line (HTR8) na omenala trophoblast bụ isi na-emeso ya ma ọ bụ na-enweghị aPL na ọnụnọ na enweghị vitamin D, LMWH ma ọ bụ abụọ.A na-atụle ihe nzuzo nke trophoblast nke cytokines na-egbuke egbuke na ihe angiogenic site na ELISA.Vitamin D naanị ma ọ bụ na-ejikọta ya na LMWH na-eme ka mmeghachi omume na-egbuke egbuke nke aPL na-ebute na sel HTR8 na omenala ndị bụ isi.Ọ bụ ezie na vitamin D enweghị mmetụta ọ bụla na mgbanwe mgbanwe nke aPL-mediated nke ihe angiogenic na trophoblast bụ isi, ọ na-egbochi LMWH-induced sFlt-1 ntọhapụ. LMWH jikọtara ya na vitamin D nwere ike ịba uru karịa ọgwụgwọ otu onye nnọchiteanya site na igbochi aPL. -induced trophoblast mbufụt na ịtụgharị LMWH-induced sFlt-1 secretion.
