Ngwaahịa

Islet amyloid polypeptide (IAPP; nke a makwaara dị ka amylin) na-ahụ maka nhazi amyloid islet na ụdị ọrịa shuga 2, a kwenyere na toxicity nke IAPP kpatara na-enye aka na mfu nke β-cell mass jikọtara ya na njedebe nke ụdị ọrịa shuga 2.Nhazi amyloid nke islet nwekwara ike na-ekere òkè na ọdịda aka aka mgbe a gbanyechara ya.A na-emepụta IAPP dị ka prohormone, pro-islet amyloid polypeptide (proIAPP), ma hazie ya na granules nzuzo nke sel β-pancreatic.A na-ahụ ụdị proIAPP nke edoziri nke ọma na nkwụnye ego amyloid;ihe kacha pụta ìhè bụ etiti 48 fọdụrụnụ, proIAPP(1-48), nke gụnyere N-terminal pro-extension, mana nke edoziri nke ọma na C-terminus.Nhazi na-ezughị ezu nwere ike ịrụ ọrụ na nhazi amyloid islet site n'ịkwalite mmekọrịta ya na proteoglycans sulfated nke matrix extracellular, nke, n'aka nke ya, na-akwalite nhazi amyloid.Anyị na-egosi na fuchsin acid (3-- (4-amino-3-methyl-5-sulphonatophenyl) -1- (4-amino-3-sulphonatophenyl) methylene) cyclohexa-1,4-dienesulphonic acid), dị mfe. sulfonated triphenyl methyl derivative, bụ ihe mgbochi siri ike nke nhazi amyloid site na proIAPP (1-48) etiti.Ihe mgbagwoju anya triphenyl methane na-enweta ngwa ngwa FCF (ethyl-[4-[4-[ethyl-[(3-sulfophenyl)methyl]amino]phenyl]-(4-hydroxy-2-sulfophenyl) methylidene]-1-cyclohexa -2,5-dienylidene] -[(3-sulfophenyl) methyl] azanium} na-egbochikwa nhazi amyloid site na IAPP na proIAPP nhazi etiti.Ngwakọta abụọ a na-egbochi nhazi amyloid site na ngwakọta nke etiti proIAPP na ụdị glycosaminoglycan heparan sulfate.Acid fuchsin na-egbochikwa nguzobe amyloid nke glycosaminoglycan sitere na IAPP tozuru oke.Ikike nke igbochi nguzobe amyloid abụghị naanị n'ihi ogige ndị a na-ekpo ọkụ, ebe ọ bụ na sulfonated inhibitor nke amyloid-β, tramiprosate, abụghị onye na-egbochi etolite amyloid site na proIAPP (1-48).