Ngwaahịa

Egosiputala protein cerebral dopamine neurotrophic factor (CDNF) iji kpuchido ụzọ nigrostriatal dopaminergic mgbe enyere ya dị ka infusions intrastriatal na oke na ụdị òké nke ọrịa Parkinson (PD).N'ime ọmụmụ ihe a, anyị tụlere mmetụta neuroprotective nke CDNF ewepụtara na recombinant adeno-associated viral (AAV) serotype 2 vector na oke 6-hydroxydopamine (6-OHDA) ụdị PD.Vectors AAV2 na-edobe CDNF, glial cell line-derived neurotrophic factor (GDNF), ma ọ bụ protein fluorescent green ka etinyere n'ime oke striatum.Nyocha okwu protein gosipụtara na vector AAV2 anyị na-ebunye mkpụrụ ndụ ihe nketa neurotrophic nke ọma n'ime ụbụrụ wee mepụta nkwupụta protein ndị ahụ na-adịte aka.Izu abụọ ka AAV2 vector injection, 6-OHDA gbabara n'ime oke striatum, na-emepụta mmebi na-aga n'ihu nke usoro nigrostriatal dopaminergic.Ọgwụgwọ na AAV2-CDNF butere mbelata nke ukwuu na ntụgharị ipsilateral nke amphetamine na-ebute ebe ọ na-enye naanị nchekwa nke tyrosine hydroxylase (TH) -immunoreactive cell na oke substantia nigra pars compacta na TH-reactive fibers na striatum.Nsonaazụ sitere na ọmụmụ ihe a na-enyekwu ihe akaebe na CDNF nwere ike iwere dịka ọgwụgwọ nwere ike ịgwọ ọrịa ọrịa Parkinson.