Ngwaahịa

Hyperpermeability nke vaskụla na-enye aka na ọrịa na-efe efe na mbufụt.Usoro dị ugbu a maka ntule in vivo nke permeability dabere na mpụ nke albumin nke Evans Blue (EB) na-ekekọta dị njọ ma na-enwekarị nghọta.Anyị mepụtara usoro infrared fluorescence (IRF) nke akwụkwọ akụkọ maka nha nke EB-albumin extravasation iji kọwaa permeability vaskụla na ụdị murine.A na-enyocha permeability nke vaskụla nke endotoxaemia kpatara maka akụkụ ahụ siri ike, ụbụrụ, akpụkpọ ahụ na peritoneum site na IRF na nha nke dabere na nnabata nke EB na mpụta anụ ahụ.Akụkụ IRF mụbara n'ahịrị na-abawanye ụba nke EB intravenous (2.5-25 mg/kg).Tissue IRF nwere mmetụta karịa maka mkpokọta EB ma e jiri ya tụnyere usoro dabere na nnabata.N'ihi ya, ndịiche dị na vaskụla permeability na EB akụkụ EB n'etiti lipopolysaccharide na-agwọ ọrịa na ụmụ oke saline na-abụkarị ihe dị ịrịba ama mgbe nyocha nke dabeere na IRF ma ọ bụghị site na nchọpụta dabeere na ntinye.Achọpụtara EB na akụkụ 353 niile ejiri IRF nyochara mana naanị na 67% (239/353) nke akụkụ ahụ nyochara site na usoro dabere na nnabata, na-egosipụta mmụba nke nchọpụta EB na akụkụ nwere IRF.N'ụzọ dị iche, EB na plasma mgbe nchịkwa EB na-enyocha ngwa ngwa site na ụzọ abụọ ahụ nwere njikọ dị elu n'etiti ụzọ abụọ ahụ (n=116, r2=0.86).Ọnụ ọgụgụ nke EB-IRF dị iche iche nke akụkụ ahụ kpọmkwem n'ihi endotoxin dị mma mgbe atụnyere IRF n'etiti ụmụ oke dakọtara maka ịdị arọ, okike, na afọ, yana mgbazi kwesịrị ekwesị maka ịdị arọ nke akụkụ ahụ na mkpokọta plasma EB.N'ụzọ doro anya, usoro EB-IRF na-ahapụ akụkụ ahụ emebibeghị maka histopathology na-esote.Na nchịkọta, EB-IRF bụ akwụkwọ akụkọ, nke nwere mmetụta siri ike, usoro dị ngwa na nke dabara adaba maka ọnụọgụ EB n'ime akụkụ ọgwụgwọ na-adịghị mma megide ụmụ oke njikwa.