Ngwaahịa

Mmụba nrụgide oxidative n'okpuru ọnọdụ hyperglycemic, site na mmekọrịta nke AGEs na ndị na-anabata RAGE yana site na ịgbalite akara ntụgharị mgbasa ozi interleukin, ka akọpụtala na ọrịa kansa.A na-enyocha mgbanwe ndị na-edozi maka ọrụ ha na mmepe na ọganihu nke ọrịa cancer na nzaghachi autoantibody megide ha na-enweta mmasị dị ka nyocha maka nchọpụta mbụ nke ọrịa ahụ.Ọmụmụ ihe a enyochala mgbanwe na histone H1 na mgbanwe nke methylglyoxal (MG) na ihe ọ pụtara na autoimmunopathogenesis nke ọrịa kansa.Histone gbanwere gosipụtara mgbanwe na ihe ndị na-esi ísì ụtọ, gbanwere microenvironment tyrosine, njikọ intermolecular cross na ọgbọ nke AGE.Ọ gosipụtara nkpuchi nke patches hydrophobic na mgbanwe hypsochromic na ọkụ ọkụ ANS akọwapụtara.MG na-eme ihe ike oxidized histone H1 na-eduga na mkpokọta nke carbonyls reactive.Ntụle CD dị anya na-egosi mmụba nke di-carbonyl nke nhazi alfa yana ntinye nke nhazi mpempe akwụkwọ beta;na thermal denaturation (Tm) ọmụmụ kwadoro nkwụsi ike nke okpomọkụ nke histone gbanwetụrụ.Nyocha FTIR gosipụtara ngbanwe nke amide I band, ọgbọ nke otu carboxyethyl na mkpọtụ N-CA na histone gbanwetụrụ.Nyocha LCMS kwadoro nguzobe nke Nε- (carboxyethyl) lysine na nyocha microscopic nke eletrọn kpughere nhazi mkpokọta amorphous.Akụkọ ihe mere eme emezigharịrị gosipụtara njikọ mmekọrịta ya na DNA gbanwere.Mgbanwe H1 butere ọgwụ mgbochi titre dị elu n'ime oke bekee yana ụdị sera nke oke bekee dịpụrụ adịpụ nke IgG gbanyere ọgwụ mgbochi H1 emezigharịrị gosipụtara njikọ a kapịrị ọnụ yana immunogen ya na nyocha Western Blot.IgG dịpụrụ adịpụ na sera nke ndị ọrịa nwere ọrịa cancer akpa ume, ọrịa prostate, ọrịa ara ara na ọrịa kansa nke isi na mpaghara olu gosipụtara mmata dị mma maka neo-epitopes na histone gbanwetụrụ, na-egosipụta ọnụnọ nke autoantibodies na-ekesa na ọrịa kansa.Ebe ọ bụ na akụkọ na-atụ aro njikọ dị n'etiti AGE-RAGE axis na carcinogenesis, glycoxidation nke histone H1 na immunogenicity ya na-emeghe ụzọ maka ịghọta ọrụ protein glycoxidative mebiri emebi na ọrịa kansa.