DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) CAS: 28718-90-3 99% ntụ ntụ edo edo
| Nọmba katalọgụ | XD90505 |
| Aha ngwaahịa | DAPI (4,6-Diamidino-2-phenylindole dihydrochloride) |
| CAS | 28718-90-3 |
| Usoro ihe omimi | C16H15N5 · 2HCl |
| Ibu molekụla | 350.25 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 2933998090 |
Nkọwapụta ngwaahịa
| Ọdịdị | Acha odo odo ntụ ntụ |
| Nyocha | 99% nkeji |
| Maka iji nyocha naanị, ọ bụghị maka ojiji mmadụ | A na-eji nyocha naanị, ọ bụghị maka mmadụ |
Melatonin na-etinye aka n'ọtụtụ ọrụ physiological, ọ nwekwara mmetụta dị iche iche na apoptosis na mkpụrụ ndụ nkịtị na ọrịa cancer.Otú ọ dị, usoro nke ọrụ antitumor ya aghọtachaghị nke ọma.N'ime ọmụmụ ihe a, anyị na-egosi na melatonin na-eme ka apoptosis nke tunicamycin na-ebute na carcinoma ara mmadụ MDA-MB-231 cell.Melatonin na-achịkwa okwu Bim pro-apoptotic pro-apoptotic na ọkwa ederede na ọnụnọ tunicamycin.Melatonin na-egbochi okwu COX-2 na-ebute tunicamycin na sel MDA-MB-231.Ọzọkwa, igbochi ọrụ COX-2 site na iji COX-2 inhibitor, NS398, na-abawanye apoptosis na-ebute tunicamycin.N'ụzọ na-akpali mmasị, mmetụta ndị a ejikọtaghị na ụzọ mgbama nnabata melatonin.Pertussis toxin (onye na-egbochi protein protein n'ozuzu) ma ọ bụ luzindole (onye na-anabata melatonin na-anabataghị nke ọma) ewepụghị mmetụta nke melatonin.Na mgbakwunye, melatonin gbochiri tunicamycin-induced NF-κB transcriptal transcriptal, p65 nuclear translocation, na p38 MAPK eme ivation.Mgbochi p38 MAPK nke melatonin gbakọrọ aka nyere aka na mbelata nkwụsi ike COX-2 mRNA.N'ịchịkọta ọnụ, nsonaazụ anyị na-atụ aro na melatonin na-eme ka ọrụ antitumor dịkwuo elu site na nhazi ọkwa nke okwu Bim na nhazi nke okwu COX-2 na sel MDA-MB-231 nke tunicamycin na-agwọ.
