Ngwaahịa

Emepụtara ihe nkiri mucoadhesive nwere nanoparticles curcumin na-ebu, na-achọ ịgbatị oge obibi nke ụdị usoro onunu ogwu na oghere ọnụ yana ịbawanye nnabata ọgwụ site na mucosa buccal.Emebere ihe nkiri site na usoro nkedo ka etinyere curcumin nanoparticles polycaprolactone nwere mkpuchi chitosan n'ime ngwọta chitosan plasticized.A na-eji nnukwu molar dị iche iche nke mucoadhesive polysaccharide chitosan na ntinye nke plasticizer glycerol iji kwalite ọnọdụ nkwadebe.Achọpụtara ihe nkiri ndị e nwetara site na iji ọkara na nnukwu molar mass chitosan bụ otu na mgbanwe.A na-ekesa nanoparticles ndị curcumin juru n'otu n'otu n'elu ihe nkiri ahụ, dị ka egosipụtara site na microscopy ike atomic na elu-emission egbe nyocha eletrọn microscopy (FEG-SEM).Nyocha nke akụkụ ihe nkiri na-eji FEG-SEM gosipụtara ọnụnọ nke nanoparticles n'ime ihe nkiri ahụ.Tụkwasị na nke ahụ, ihe nkiri gosipụtara na ha nwere ezigbo mmiri mmiri na ngwọta mmiri simulated, na-egosipụta ọzịza kachasị nke gburugburu 80% na in vitro na-achịkwa ogologo oge nke curcumin.Nsonaazụ ndị a na-egosi na ihe nkiri mucoadhesive nwere nanoparticles na-enye ụzọ dị mma maka nnyefe buccal nke curcumin, nke nwere ike ịba uru karịsịa n'ịgwọ ọrịa ọrịa periodontal nke chọrọ nnyefe ọgwụ na-adịgide adịgide.© 2014 Wiley Periodicals, Inc. na American Pharmacists Association.