Ngwaahịa

Otu metabolite nke eriri afọ nke ginseng protopanaxadiol saponin, 20-O- (β-D-glucopyranosyl) -20 (S) -protopanaxadiol (compound K), ka akọọrọ na ọ na-ebute apoptosis na mkpụrụ ndụ cancer dị iche iche.Agbanyeghị, usoro izizi nke K na-akpata na mkpụrụ ndụ hepatocellular carcinoma (HCC) ka edobeghị anya.Iji nyochaa usoro apoptotic enwere ike, anyị nyochara mmetụta anticancer nke compound K na MHCC97-H.MTT nyocha gosiri na ogige K gbochiri mmụba nke mkpụrụ ndụ MHCC97-H nwere obere nsi na mkpụrụ ndụ hepatoma nkịtị.Ọganihu okirikiri cell na ntụpọ cell gosipụtara mmụba na obere akụkụ-G1 apoptotic.Ọgwụgwọ nke MHCC97-H na ngwakọta K mekwara ka mbelata nke ike akpụkpọ anụ mitochondrial (Δψm) na mmebi DNA.Ọmụmụ ihe ọzọ gosiri na compound K na-akwado Fas, FasL, Bax / Bcl-2 ratio na pro-caspase-9, pro-caspase-3 na-adabere na dose-based, na ọ na-egbochikwa Akt phosphorylation.Nsonaazụ ndị a na-atụ aro na ngwakọta K nke ukwuu na-egbochi mmụba cell ma na-ebute apoptosis na mkpụrụ ndụ MHCC97-H site na ụzọ Fas- na mitochondria-mediated caspase-based paths na sel HCC mmadụ.