![Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl) -methane Cas: 6976-37-0 99% Foto egosipụtara](http://cdn.globalso.com/xdbiochems/6976-37-0.jpg)
Bis[2-Hydroxyethyl] imino Tris-(Hydroxymethyl) -methane Cas: 6976-37-0 99%
| Nọmba katalọgụ | XD90111 |
| Aha ngwaahịa | BIS-TRIS (Bis (2-hydroxyethyl) amino-tris (hydroxymethyl) methane) |
| CAS | 6976-37-0 |
| Usoro ihe omimi | C8H20NO5 |
| Ibu molekụla | 210.2476 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 2922190090 |
Nkọwapụta ngwaahịa
| Ọla dị arọ | <10ppm |
| Ihe fọdụrụ na mgbanye | <0.1% |
| Pka | 6.3-6.7 |
| Ọdịdị | White Crystalline ntụ ntụ |
| Solubility (1M na H20) | Kpochapụ ma zuo oke |
| pH (1M na H2O) | 9.0-11.0 |
| Mmiri (LOD) | 1.0% kacha. |
| Nyocha (Titration na akọrọ ndabere) | 99.0% nkeji. |
Buffer, eji maka nchọpụta creatine-creatinase;a na-ejikwa ya maka nchebe dị irè nke hemoglobin na-ehicha nkụ;catholyte, eji na IEF/2-D gel electrophoresis.
Glial cell line-derived neurotrophic factor (GDNF) bụ ihe na-egbochi ethanol oriri na nlọghachi azụ, na GDNF heterozygous knockout ụmụ oke na-egosipụta mmụba ụgwọ ọrụ na ethanol ma na-eri ọtụtụ ethanol mgbe oge abstinence karịa ụdị anụ ọhịa ha.N'ebe a, anyị nwalere ma ethanol na-agbanwe okwu GDNF na mpaghara ventral tegmental (VTA; GDNF saịtị nke omume) na / ma ọ bụ nucleus accumbens (NAc; isi iyi nke GDNF), ma ọ bụrụ otú ahụ, chọpụta ọrụ nke ihe na-eto eto endogenous. na usoro nke oriri ethanol.Nlekọta usoro nke ethanol mụbara okwu GDNF na ọkwa protein na VTA, mana ọ bụghị NAc.Na mgbakwunye, a na-ebuli ọkwa GDNF elu mgbe nnọkọ mmanya ethanol riri na oke ndị na-eri ethanol n'ime usoro nhọrọ karama abụọ na-akwụsịtụ maka izu 1, mana ọ bụghị izu 7.Mbelata na-esochi izu 7 nke oriri ethanol gabigara ókè belatara ọkwa GDNF, ebe obere oge mmanya na-egbu mmanya ethanol na-eso mwepu kwalite okwu GDNF.N'ụzọ dị mkpa, ịkụda GDNF n'ime VTA site na iji adenovirus na-ekwupụta ntutu dị mkpụmkpụ RNA mere ka mmụba nke ethanol dị elu site na oke ethanol-naïve, ma ọ bụghị site na oke nwere akụkọ ihe mere eme nke ịṅụbiga mmanya ókè ethanol.Nsonaazụ ndị a na-egosi na n'oge ahụmahụ mbụ ethanol-ịṅụ mmanya, GDNF na VTA na-abawanye ma na-echebe megide mmepe nke oke ethanol oriri.Otú ọ dị, nzaghachi nchebe nke ihe na-eto eto na ethanol na-akụda mgbe ịṅụbiga mmanya ókè na nkwụsị ethanol dị ogologo, na-ebute oriri ethanol na-adịgide adịgide.
