Ngwaahịa

Otu atọ nke nnukwu cynomolgus enwe (Macaca fascicularis) bụ 200 micrograms/m3 ammonium hexachloroplatinate [(NH4) 2PtCl6], 200 micrograms (NH4) 2PtCl6 na 1 ppm ozone (O3), ma ọ bụ naanị .1.E kpughere anụmanụ ndị ahụ site na iku ume maka awa 6 kwa ụbọchị, ụbọchị 5 kwa izu maka izu iri na abụọ.Nnwale nnwale ahụ gụnyere preexposure methacholine na nyocha ihe ịma aka bronchoprovocation Na2PtCl6, ule akpụkpọ anụ ọnụ ụzọ Na2PtCl6, na sera maka nyocha nke ọgwụ mgbochi.Izu abụọ ka ihe ngosi 12-wk gasịrị, a tụlegharịrị otu indices ndị a.Baseline pulmonary ọrụ emetụtaghị nke ukwuu site na usoro ikpughe;Otú ọ dị, nchikota nke ikpughe na O3 na (NH4) 2PtCl6 budata ibelata ntinye nke platinum (Pt) nnu na methacholine dị mkpa iji mee ka nkwụsị nke mgbaba nke akpa ume (RL) 200% (EC200 RL).Ozone ma ọ bụ Pt naanị ekpughere enweghị mmetụta dị ukwuu na paramita ndị a.A na-ejikọta ụkpụrụ Platinum na methacholine EC200 RL nke ukwuu maka otu abụọ ekpughere Pt mgbe ekpughere ya.Ihe omuma a gosiputara na nchikota O3 na Pt na-abawanye nke ukwuu (Pt) na nonspecific (methacholine) hyperreactivity bronchial ugboro ugboro karia ikpughe na O3 ma ọ bụ Pt nnu naanị.Ngwakọta O3 gbakwunyere Pt ekpughere na-abawanye nke ukwuu nleba anya nke nyocha anụ ahụ Pt dị mma ma e jiri ya tụnyere ndị otu mgbasa ozi ndị ọzọ.Dị ka ahụmihe mmadụ, nnwale redioallergosorbent (RAST) maka ọgwụ mgbochi Pt adịghị enwe mmetụta dị ka nnwale anụ ahụ kpọmkwem n'ịchọpụta ndị na-ahụ nfụkasị ahụ.