Ngwaahịa

Neuroblastoma, ọrịa cancer nke sistem obi ọmịiko, bụ etuto siri ike nke na-adịkarị na ụmụaka.MYCN mmụba na mmụba BDNF/TrkB na-egosi bụ njirimara nke etuto ahụ dị elu;ma, naanị ˜25% nke etuto ọjọọ na-egosipụta njirimara ndị a.Ya mere, njirimara nke ndị ọzọ biomarkers na ọgwụgwọ ọgwụgwọ dị mkpa.Dị ka aminoacylase 1 (ACY1), amino acid deacetylase, bụ ihe na-egbochi akpụ akpụ na obere akpa ume na renal cell carcinomas, anyị nyochara ma ya ma ọ bụ ndị ezinụlọ ndị ọzọ aspartoacylase (ASPA, aminoacylase 2) ma ọ bụ aminoacylase 3 (ACY3) nwere ike ije ozi. ọrụ yiri nke ahụ na neuroblastoma.A na-enyocha okwu Aminoacylase na TrkB-positive, MYCN-amplified (SMS-KCNR na SK-N-BE) na TrkB-negative, na-abụghị MYCN-amplified (SK-N-AS, SK-N-SH, SH-SY5Y na SH-EP) ahịrị sel neuroblastoma.Aminoacylase nke ọ bụla gosipụtara ọnọdụ oghere dị iche iche (ya bụ, cytosolic ACY1, akpụkpọ ahụ metụtara ASPA na nuklia ACY3).Mgbe a na-emeso mkpụrụ ndụ SK-N-SH site na ndị ọrụ dị iche iche nke akwara (dịka ọmụmaatụ, retinoic acid na cAMP) na mgbasa ozi nwere 10% serum, ACY1 bụ nanị aminoacylase nke a na-edozi okwu ya.E gosipụtara ASPA n'ụzọ bụ isi na sel SH-EP nke glial sublineage.Akọwapụtara ACY3 nke ukwuu na ahịrị TrkB dị mma, MYCN na-abawanye.A na-egosipụta aminoacylase atọ niile na gland adrenal mmadụ nkịtị, ebe a na-ahụkarị neuroblastoma, mana naanị ACY1 na ACY3 gosipụtara ngosipụta a na-achọpụta na ụbụrụ neuroblastoma bụ isi.Ngwuputa data bioinformatics nke ndụ Kaplan-Meier kpughere na okwu ACY3 dị elu jikọtara ya na amụma na-adịghị mma, ebe okwu dị ala nke ACY1 ma ọ bụ ASPA jikọtara ya na prognosis na-adịghị mma.Ihe omuma a na-egosi na a na-edozi okwu aminoacylase na neuroblastoma