Ngwaahịa

Ọtụtụ ọgwụ mgbochi ọrịa cancer adịghị ekpochapụ etuto ahụ, na-eduga na mmepe nke nguzogide ọgwụ na nlọghachi ọrịa.Ngosipụta Hedgehog na-arụ ọrụ dị oke mkpa n'oge mmepe embrayo, mana ọ na-etinyekwa aka na mmepe cancer, ọganihu, na metastasis.The Hedgehog receptor Patched (Ptc) bụ mkpụrụ ndụ ihe na-egosi Hedgehog nke na-egosipụta oke n'ọtụtụ mkpụrụ ndụ kansa.N'ebe a, anyị na-egosi njikọ dị n'etiti Ptc na iguzogide chemotherapy, ma nye nghọta ọhụrụ banyere ọrụ Ptc.A na-ekpochapụ Ptc na akpụkpọ ahụ plasma mgbe ya na ligand Hedgehog na-emekọrịta ihe, ma ọ bụ na ọgwụgwọ sel na Hedgehog na-egosi cyclopamine antagonist.N'okwu abụọ ahụ, mgbe ntinye nke sel na doxorubicin, onye na-ahụ maka chemotherapeutic nke a na-eji maka nlekọta ahụike nke ọrịa cancer na-emekarị, anyị hụrụ nkwụsị nke doxorubicin si na fibroblasts na-aza Hedgehog, na mmụba nke nchịkọta doxorubicin na ọrịa cancer abụọ dị iche iche. ahịrị sel nke amaara na-egosipụta ọkwa nrịanrịa nke ihe nrịbama Hedgehog.N'iji usoro okwu heterologous, anyị gosipụtara n'ụzọ siri ike na nkwupụta nke Ptc mmadụ nyere nkwụsi ike nke igbochi uto site na ọtụtụ ọgwụ ndị na-ahụ maka chemotherapeutic dị ka doxorubicin, methotrexate, temozolomide, na 5-fluorouracil.Nguzogide doxorubicin jikọtara ya na ọrụ Ptc, dị ka egosipụtara site na iji mmụgharị sitere na ndị ọrịa Gorlin's syndrome nke mmetụta Ptc-mediated na akara Hedgehog na-efunahụ.Nsonaazụ anyị na-egosi na Ptc na-etinye aka na nsị ọgwụ na nguzogide ọtụtụ ọgwụ, ma na-atụ aro na Ptc na-enye aka na nguzogide chemotherapy nke mkpụrụ ndụ kansa.