5-Methylphenazinium methosulfate Cas: 299-11-6 99% Akwụkwọ ndụ akwụkwọ ndụ gbara ọchịchịrị ruo ntụ ntụ aja aja
| Nọmba katalọgụ | XD90224 |
| Aha ngwaahịa | 5-Methylphenazinium methosulfate |
| CAS | 299-11-6 |
| Usoro ihe omimi | C14H14N2O4S |
| Ibu molekụla | 306.337 |
| Nkọwa nchekwa | -15 ruo -20 Celsius |
| Koodu tarifu akwadoro | 29339980 |
Nkọwapụta ngwaahịa
| Ebe mgbaze | 158-160 Celsius C (dec.) (ọkụ) |
| Nyocha | 99% |
| Ụdị | siri ike |
| Ọdịdị | Akwụkwọ ndụ akwụkwọ ndụ gbara ọchịchịrị ruo ntụ ntụ aja aja |
Egosiputara n-3 polyunsaturated fatty acids eicosapentaenoic acid (EPA) na docosahexaenoic acid (DHA) iji kwalite mmetụta nke ọgwụ chemotherapeutic na ọmụmụ ụlọ ọgwụ na ndị ọrịa cancer na ime ka apoptotic tumor cell ọnwụ na vitro.Ruo ugbu a, enyochabeghị EPA na DHA na otutu myeloma (MM).Mkpụrụ ndụ myeloma mmadụ (L363, OPM-1, OPM-2 na U266) na mkpụrụ ndụ mononuclear nkịtị dị n'akụkụ ọbara ka ekpughere na EPA na DHA, yana mmetụta na ọrụ mitochondrial na apoptosis, ịgbalite caspase-3, okwu mkpụrụ ndụ ihe nketa na nsí ọgwụ.Ngosipụta na EPA na DHA butere apoptosis na mmụba nke bortezomib na sel MM.N'ụzọ dị mkpa, ha emetụtaghị ndụ nke mkpụrụ ndụ mononuclear nkịtị mmadụ.Usoro okwu nke ozi RNA gosipụtara na mkpụrụ ndụ ihe nketa EPA na DHA na-etinye aka n'ọtụtụ ụzọ akara gụnyere ihe nuklia (NF) κB, Notch, Hedgehog, nrụgide oxidative na Wnt.EPA na DHA gbochiri ọrụ NFκB wee bute apo ptosis site na nrụrụ mitochondrial na ịgbalite caspase-3.Ọmụmụ ihe anyị na-atụ aro na EPA na DHA na-ebute mmetụta cytotoxic na-ahọrọ na MM ma na-amụba uche na bortezomib ma na-akpọ maka nyocha ọzọ n'ime ngwa nke n-3 polyunsaturated fatty acids ndị a na ọgwụgwọ MM.
