A mụrụ biosynthesis nke proteoglycans na glycosaminoglycans n'ihu p-nitrophenyl-xyloside site na iji usoro omenala sel sel granulosa bụ isi nke oke ovarian.Mgbakwunye nke p-nitrophenyl-xyloside n'ime usoro omenala cell kpatara ihe dị ka 700% mmụba nke [35S] sulfate incorporation (ED50 na 0.03 mM) n'ime macromolecules, nke gụnyere free chondroitin sulfate chains malitere na xyloside na ụmụ amaala proteoglycans.Agbụ nke chondroitin sulfate efu ewelitere na xyloside fọrọ nke nta ka ezobe ya naanị n'ime ọkara.Ọnụ ọgụgụ molekụla nke ụdọ chondroitin sulfate belatara site na 40,000 ruo 21,000 ka mkpokọta [35S] sulfate incorporation na-abawanye, na-atụ aro na nkwalite njikọ nke chondroitin sulfate na-akpaghasị usoro nkịtị nke njedebe glycosaminoglycan.Biosynthesis nke heparan sulfate proteoglycans belatara ihe dịka 50%, ikekwe n'ihi asọmpi na ọkwa nke UDP-sugar precursors.[35S] E mechibidoro ntinye nke sulfate site na mgbakwunye nke cycloheximide na ọkara mbụ nke ihe dịka 2 hr na ọnụnọ nke xyloside, ebe na enweghị xyloside dị ihe dị ka 20 min.Ọdịiche a nwere ike na-egosipụta ọnụọgụ ntụgharị nke glycosaminoglycan na-emepụta ikike n'ozuzu ya.Ọnụego ngbanwe nke glycosaminoglycan synthesizing ikike hụrụ na mkpụrụ ndụ granulosa ovarian dị mkpụmkpụ karịa nke a hụrụ na chondrocytes, na-egosipụta ikike ikike proteoglycan biosynthetic na mkpokọta ọrụ metabolic nke sel.
