Abụọ isomeric bicyclo [4.1.0] heptane analogues nke glycosidase inhibitor galacto-validamine, (1R *,2S,3S,4S,5S,6S*) -5-amino-1- (hydroxymethyl) bicyclo[4.1.0] heptane. -2,3,4-triol, ka ejirila usoro 13 si na 2,3,4,6-tetra-O-benzyl-D-galactose.A tụrụ ọrụ mgbochi nke amines abụọ a na-egbochi conformationally, yana acetamides kwekọrọ, megide enzymes alfa-galactosidase azụmahịa sitere na kọfị kọfị na E. coli.Ọrụ nke ezinụlọ glycosyl hydrolase GH27 enzyme (kọfị kọfị) bụ nke 1R,6S-amine (7) gbochiri asọmpi nke ọma, njikọ njikọ nke ejiri K (i) uru nke 0.541 microM mara.GH36 E. coli alpha-galactosidase gosipụtara mmekọrịta na-adịghị ike nke ukwuu na 1R,6S-amine (IC(50)= 80 microM).Diastereomeric 1S,6R-amine (9) na-ejikọta ya na galactosidases abụọ, (kọfị kọfị, IC (50) = 286 microM) na (E. coli, IC (50) = 2.46 mM).
