Ngwaahịa

1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine bụ ihe mejupụtara kemịkalụ nwere ngwa ngwa dị iche iche na kemistri ọgwụ na mmepe ọgwụ. , kpọmkwem na nchọpụta ọgwụ.Ọnụnọ nke otu hydroxymethylpyridinyl na-egosi mmekọrịta enwere ike na ebumnuche ndu, dị ka enzymes ma ọ bụ ndị na-anabata ya.Ndị na-ahụ maka ọgwụ na-agwọ ọrịa nwere ike ịkwalite nhazi nke ogige a iji kwalite njikọ ya na nhọrọ ya na ebumnuche ndu ndị a chọrọ.Site n'ịgbanwe usoro phenyl na piperazine, ndị na-eme nchọpụta nwere ike imeziwanye ihe ndị mejupụtara physicochemical Njirimara na pharmacokinetics nke ogige ahụ, nke nwere ike ime ka ọ dịkwuo mma ọgwụ ọjọọ ma belata mmetụta ndị na-achọghị. Ngwa ọzọ nke 1- (3-Hydroxymethylpyridin-2-yl) -4. -methyl-2-phenylpiperazine dị na ngalaba nke neuropharmacology.Nhazi nke ogige a na-egosi mmekọrịta enwere ike na ndị na-anabata ya na sistemu ụjọ nke etiti, nke nwere ike ibute nsonaazụ ọgwụgwọ na nsogbu akwara ozi.Dịka ọmụmaatụ, enwere ike inyocha ya dị ka onye na-eme mgbanwe maka mgbanwe neurotransmission na ọnọdụ dị ka nchekasị, ịda mbà n'obi, ma ọ bụ schizophrenia.Ndị na-eme nchọpụta nwere ike nyochaa usoro ihe eji eme ihe na-eme ihe ma na-eduzi ọmụmụ ihe kpọmkwem na ụlọ ọgwụ iji chọpụta ike ọgwụgwọ ya. Ọzọkwa, atụmatụ nhazi nke ogige a nwere ike ime ka ọ dị mma maka ngwa nnyefe ọgwụ.Otu phenyl hydrophobic ya na methyl na-atụ aro ikike ịgafe membranes lipid, na-enyere ya aka ileba anya enzymes intracellular ma ọ bụ ụzọ.Ngwongwo a bara uru maka ịmepụta ọgwụ ndị chọrọ ịbanye n'ime sel ma tinye mmetụta ha na ebumnuche intracellular kpọmkwem.Site n'ịgbanwe nhazi nke ogige ahụ, ndị na-ahụ maka ọgwụ ọgwụ nwere ike ịkwalite bioavailability ya, meziwanye nkwụsi ike ya, ma mepụta usoro nnyefe ọgwụ dị irè. Ọ dị mkpa ịmara na iji 1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2 -phenylpiperazine na ngwa ndị a nwere ike chọrọ nyocha nke ọma na nyocha ụlọ ọgwụ iji hụ na nchekwa, nrụpụta ọrụ na usoro ọgwụgwọ kwesịrị ekwesị.Nnukwu ihe ọmụmụ ọgwụ na toxicological dị mkpa iji ghọta mmetụta ya na usoro ndu dị iche iche na iji chọpụta mmetụta ọjọọ ọ bụla nwere ike ime.Na nchịkọta, 1- (3-Hydroxymethylpyridin-2-yl) -4-methyl-2-phenylpiperazine bụ onyinye dị iche iche. ngwa nwere ike na kemịkalụ ọgwụ na mmepe ọgwụ.Ọ na-ekwe nkwa maka imepụta ọgwụ ọhụrụ, karịsịa na mpaghara neuropharmacology na nnyefe ọgwụ.Ọ dị mkpa nyocha ọzọ iji nyochaa mmekọrịta ya kpọmkwem, usoro omume, na ike ọgwụgwọ ya, na-emeghe ụzọ maka ọganihu nwere ike ime n'ịgwọ ọrịa na nsogbu dị iche iche.