Ngwaahịa

1- (3-Carboxypyrid-2-yl) -2-phenyl-4-methyl-piperazine, nke a makwaara dị ka CPPMP, bụ ngwakọta kemịkalụ nwere usoro dị mgbagwoju anya nke nwere ngwa dị iche iche nwere ike na ngalaba ọgwụ kemịkalụ.One nwere ike iji. nke CPPMP nọ na ọgwụgwọ ọrịa akwara ozi.Ọnụnọ nke otu carboxypyridyl na-egosi ike ya maka mmekọrịta ya na ndị na-anabata neuronal kpọmkwem na sistemu ụjọ nke etiti.Ezubere iche ndị nnabata ndị a nwere ike gbanwee neurotransmission, nwere ike ibute nsonaazụ ọgwụgwọ na ọnọdụ dị ka ịda mbà n'obi, nchekasị, ma ọ bụ ọrịa neurodegenerative.Nchoputa ndi ozo choro iji choputa mmekorita nke ndi nnata na usoro ihe omume nke CPPMP ka o wee buliri ike ya dika ihe ogwugwu maka nsogbu akwara ozi.CPPMP's piperazine core Ọdịdị na-egosikwa ike ya dị ka ihe na-edu ndú maka ịmepụta ọgwụ ọhụrụ.Ndị na-ahụ maka ọgwụ ọgwụ nwere ike gbanwee akụkụ dị iche iche nke nhazi ya iji kwalite akụrụngwa ọgwụ ya ma ọ bụ lekwasịrị anya n'ụzọ ndụ ụfọdụ.Site n'ịkwalite usoro CPPMP, ndị na-eme nchọpụta nwere ike ịmepụta ihe ndị na-emepụta ihe na-emeziwanye nhọrọ, ike, na profaịlụ nchekwa, na-eme ka ha bụrụ ndị kwesịrị ekwesị maka ọgwụ na-ezubere iche maka ọrịa dị iche iche. Ọzọkwa, CPPMP's phenyl na methyl group na-enye ihe ndị dị na hydrophobic, nke nwere ike ịba uru n'ịmepụta ọgwụ ndị nwere ike ịgafe. membranes cell na ịnweta ebumnuche intracellular.Enwere ike itinye atụmatụ a iji chepụta ọgwụ ọhụrụ nke na-elekwasị anya enzymes intracellular ma ọ bụ ụzọ, na-enye ohere maka ọgwụgwọ ọgwụgwọ na ọrịa ndị dị ka ọrịa cancer ma ọ bụ ọrịa metabolic. Na mgbakwunye, njirimara pụrụ iche nke CPPMP na-enye ohere maka mmepe nke prodrugs ma ọ bụ usoro nnyefe ọgwụ. .Site n'ịgbanwe otu carboxypyridyl ya, enwere ike ịhazi ogige ahụ ka ọ kwụsie ike ma ọ bụ na-adịchaghị egbu egbu n'ụdị ala ya, ebe ọ na-ebuga akụkụ ọgwụ na-arụ ọrụ nke ọma na saịtị achọrọ.Mgbanwe ndị dị otú ahụ nwere ike ịkwalite bioavailability na ọgwụgwọ ọgwụgwọ nke ogige ahụ. Ekwesịrị iburu n'uche na iji CPPMP mee ihe na ngwa ndị a nwere ike ịkọwapụta na ọ ga-achọ nchọpụta dị ịrịba ama na mmepe tupu iji ya eme ihe.Ọzọkwa, ojiji niile nke CPPMP ga-achọ ịgbaso ụkpụrụ nchekwa nchekwa na ụkpụrụ iji hụ na njikwa kwesịrị ekwesị ma belata ihe egwu. , na-ekwe nkwa maka ngwa dị iche iche na kemistri ọgwụ.Ọdịdị ya dị mgbagwoju anya na-enye ohere maka mmepe nke ndị na-ahụ maka ọgwụgwọ ọhụụ maka ọrịa akwara ozi, yana ọgwụ ndị na-elekwasị anya ọrịa dị iche iche.Site n'inyocha nyocha na njikarịcha, CPPMP nwere ike inye aka dị ukwuu na ngalaba ọgwụ yana melite nsonaazụ onye ọrịa.