Uridine,2′-deoxy-5-ethynyl- Cas:61135-33-9
| Nọmba katalọgụ | XD90589 |
| Aha ngwaahịa | Uridine, 2'-deoxy-5-ethynyl- |
| CAS | 61135-33-9 |
| Usoro ihe omimi | C11H12N2O5 |
| Ibu molekụla | 252.23 |
| Nkọwa nchekwa | -20°C |
| Koodu tarifu akwadoro | 29349990 |
Nkọwapụta ngwaahịa
| Ọdịdị | White ka oroma ka akwụkwọ ndụ akwụkwọ ndụ ntụ ntụ ka kristal |
| Nyocha | ≥99% |
Emere ọmụmụ ihe a iji nyochaa mmetụta mmụba nke peptides soy akwukwo nri na sel ndị okenye (ASCs) na enweghị serum na usoro ha nwere ike ime.Mmụba nke mmadụ adipose anụ ahụ na-enweta mesenchymal stem cell (ADSCs) na eriri ọbara sitere na mkpụrụ ndụ mesenchymal stem cell (CB-MSC) nke a na-emeso ya na peptides soy ka achọpụtara na ọ na-abawanye nke ukwuu na 3- (4,5-dimethylthiazol-2-yl). -2,5-diphenyltetrazolium bromide na Click-iT 5-ethynyl-2'-deoxyuridine eruba cytometry nyocha.Na mgbakwunye, peptides soy dugara na phosphorylation nke p44/42 MAPK (ERK), ebumnuche anụ ahụ nke rapamycin (mTOR), p70 S6 kinase, protein S6 ribosomal protein (S6RP) na eukaryotic initiation factor 4E (eIF4E) na ADSCs.Ọzọkwa, nyocha ọnụọgụ nke cytokines gosipụtara na mmepụta nke na-agbanwe ihe na-eto eto-beta1 (TGF-β1), vaskụla endothelial growth factor na interleukin-6 mụbara nke ukwuu na nzaghachi na ọgwụgwọ na peptides soy na ADSC na CB-MSC.N'otu aka ahụ, phosphorylation soy peptide na-ebute ụzọ nke ụzọ ERK / mTOR / S6RP / eIF4E kwụsịrị na nzaghachi na pretreatment na PD98059, onye na-emechi ERK kpọmkwem.Ọzọkwa, mgbochi nke TGF-β1 site na PD98059 pretreatment na mbelata na-aga n'ihu na mgbasawanye ADSC gosipụtara na TGF-β1 na-ebute phosphorylation nke mTOR / S6RP / eIF4E.Na mkpokọta, nsonaazụ ọmụmụ a na-egosi na mmepụta nke dabere na ERK nke TGF-β1 na-arụ ọrụ dị oke mkpa na mgbasawanye soy peptide na-ebute ADSC n'okpuru ọnọdụ enweghị ọbara. Copyright © 2012 Elsevier Inc. Edebere ikike niile.
