Ngwaahịa

Nickel bụ ihe na-achọpụta nje na-akpata ọrịa nje na-efe efe nke mmadụ Helicobacter pylori.N'ezie, H. pylori nwere nickel-enzymes abụọ dị mkpa maka ịchịisi nke vivo, [NiFe] hydrogenase na urease, ihe na-akpata virulence bara ụba nke nwere 24 nickel ion kwa mgbagwoju anya.N'ihi enzymes abụọ a, nlanarị nke H. pylori na-adabere na ntinye dị mkpa nke nickel, na-egosi njikwa ike nke nkesa na nchekwa ya.Na nyocha a, anyị ga-egosi ụzọ nke ịgbalite enzymes nickel yana usoro mbụ dị na H. pylori maka ntinye, ịzụ ahịa na nkesa nke nickel n'etiti enzymes abụọ ahụ.Ndị a na-agụnye (i) usoro ntinye nickel nke dị n'èzí, onye na-ebufe FrpB4 TonB, (ii) mgbagwoju protein na netwọk mmekọrịta na-etinye aka na ịzụ ahịa nickel na nkesa n'etiti urease na hydrogenase na, (iii) Helicobacter kpọmkwem protein protein nickel. ndị na-etinye aka na nchekwa nickel ma nwee ike ịrụ ọrụ nke metallo-chaperones.N'ikpeazụ, anyị ga-atụle mmetụta nke ndị mmekọ ịzụ ahịa nickel na virulence ma tụpụta ha ka ha bụrụ ebumnuche ọgwụgwọ ọhụrụ maka ọgwụgwọ megide ọrịa H. pylori.