Ngwaahịa

Trimethoprim bụ lipophilic na adịghị ike alkaline pyrimethamine klas bacteriostatic agent.Ọ bụ ntụ ntụ ọcha na-acha ọcha ma ọ bụ ihe fọrọ nke nta ka ọ bụrụ kristal, enweghị isi, ilu, na chloroform, ethanol ma ọ bụ acetone, mana ọ fọrọ nke nta ka ọ bụrụ ihe a na-adịghị ahụkebe na mmiri yana soluble nke ukwuu na ngwọta glacial acetic acid.Ọ nwere ụdịdị nje bacteria nke yiri ọgwụ sulfa, mana nwere mmetụta antibacterial siri ike.Ọ na-enwe mmetụta dị mma n'ịgwọ ọrịa Escherichia coli, Proteus mirabilis, Klebsiella pneumoniae, Staphylococcus saprophyticus, na ọtụtụ nje bacteria na-adịghị mma na gram ndị ọzọ.Mana ọ naghị arụ ọrụ megide ọrịa Pseudomonas aeruginosa.Opekempe nke inhibitory kacha nta bụ ihe na-erughị 10 mg / L na iji naanị ya dị mfe ime ka nje na-eguzogide ọgwụ, yabụ a naghị eji ya naanị ya, yana yana ọgwụ sulfa na-etolite nkwadebe ngwakọta maka ọgwụgwọ ọrịa ọrịa urinary tract, eriri afọ. ọrịa, ọrịa iku ume, ọnyụnyụ ọbara, enteritis, typhoid fever, meningitis, otitis media, meningitis, sepsis na anụ ahụ dị nro.Ọ nwere mmetụta na ọgwụgwọ typhoid na paratyphoid mmetụta nke na-erughị ampicillin;Enwere ike ijikọ ya na ọgwụ sulf na-eme ogologo oge maka mgbochi na ọgwụgwọ ịba falciparum na-eguzogide ọgwụ.

Ụkpụrụ bụ isi nke mgbochi nje nke trimethoprim bụ igbochi folate metabolism na nje bacteria.Isi usoro a na-eme bụ igbochi nhọrọ nke ọrụ dihydrofolate reductase na nje bacteria nke mere na enweghi ike ibelata dihydrofolate ka ọ bụrụ tetrahydrofolate.Ebe ọ bụ na njikọ nke folic acid bụ akụkụ bụ isi nke nucleic acid biosynthesis, ya mere ngwaahịa ahụ na-egbochi njikọ nke nucleic acid na protein njikọ.Ọzọkwa, njikọ nke trimethoprim (TMP) na nje bacteria dihydrofolate reductase enzyme siri ike okpukpu ise karịa nke dihydrofolate reductase mammalian.Ngwakọta dị n'etiti ya na ọgwụ sulfa nwere ike ime ka mgbochi abụọ na folic acid biosynthesis metabolism nke nje bacteria nke mere na enwere mmetụta synergistic nke ga-eme ka ọrụ antibacterial nke ọgwụ sulfa dịkwuo elu, ma nwee ike gbanwee mmetụta antibacterial na mmetụta bactericidal nke na-ebelata ọgwụ na-eguzogide ọgwụ. nsogbu.Na mgbakwunye, ngwaahịa ahụ nwekwara ike ịkwalite mmetụta antibacterial nke ọtụtụ ọgwụ nje ndị ọzọ (dịka tetracycline, gentamicin).