Ngwaahịa

Trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid bụ ngwakọta kemịkalụ nke nwere ngwa dị iche iche nwere ike na ngalaba nke njikọ organic na nyocha ọgwụ.A na-akọwa ya site na ọnụnọ nke mgbanaka pyrrolidine dochie ya na tert-butoxycarbonyl (Boc) na-echebe otu na nitrogen atom na otu trifluoromethyl na mgbanaka phenyl. Otu n'ime isi ihe eji trans-1- (tert-Butoxycarbonyl) - 4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid dị ka etiti na njikọ nke ogige ndị ọzọ.Ọdịdị ya pụrụ iche na otu ndị na-arụ ọrụ na-eme ka ọ bụrụ ngọngọ ụlọ dị iche iche maka owuwu nke ụmụ irighiri ihe dị mgbagwoju anya.Otu Boc na-eje ozi dị ka otu nchekwa, nke enwere ike wepu ya n'okpuru ọnọdụ mmeghachi omume kpọmkwem iji kpughee saịtị na-arụ ọrụ maka mgbanwe ọzọ.Nke a na-enye ohere maka mgbanwe ndị a na-achịkwa na nke ziri ezi. Otu trifluoromethyl na trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3-carboxylic acid na-enyekwa ihe ndị dị mkpa na ngwa nwere ike.A maara ndị otu Trifluoromethyl maka ọdịdị eletrọn ha na-adọta na lipophilicity, nke nwere ike ịkwalite ike, nkwụsi ike nke metabolic, na bioavailability nke ndị na-achọ ọgwụ.Tụkwasị na nke ahụ, ndị otu trifluoromethyl nwere ike ịmegharị ihe onwunwe physicochemical nke ogige ahụ, na-emetụta solubility, lipophilicity, na njikọ njikọ nnabata. Ọzọkwa, trans-1- (tert-Butoxycarbonyl) -4- (3- (trifluoromethyl) phenyl) pyrrolidine-3- carboxylic acid nwere ike igosipụta ọrụ ndu n'onwe ya ma ọ bụ dị ka ọgwụ.Ọgwụ ndị na-emepụta bụ ogige ndị na-adịghị arụ ọrụ ndụ nke na-eme mgbanwe kemịkalụ ma ọ bụ enzymatic n'ime ahụ iji gbanwee ghọọ ọgwụ na-arụ ọrụ.N'ọnọdụ ụfọdụ, a na-ahọrọ ndị na-echebe Boc na vivo, na-eme ka ogige ahụ rụọ ọrụ iji nweta mmetụta ọgwụgwọ a chọrọ. phenyl) pyrrolidine-3-carboxylic acid dị ọtụtụ, nyocha ọzọ na nyocha dị mkpa iji chọpụta ikike ya zuru oke.Nke a na-agụnyekarị njikarịcha kemịkalụ ọgwụ, ọmụmụ ihe gbasara mmekọrịta omume, na nleba anya nke ndu.Site n'ịghọta nke ọma njirimara na mmeghachi omume nke ogige ahụ, ndị ọkà mmụta sayensị nwere ike ịchọpụta na ọ dabara adaba maka ichebe ọrịa ma ọ bụ ọnọdụ ụfọdụ, na-eduga na mmepe nke ndị na-achọ ọgwụ ọhụrụ ma ọ bụ ndị na-ahụ maka catalytic n'ọdịnihu.