Ngwaahịa

Tert-butyl 4- (6- (6- (1-butoxyvinyl)) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate bụ onyinye nwere nnukwu ikike na kemistri ọgwụ na mmepe ọgwụ.Usoro ihe omimi ya dị mgbagwoju anya na-egosi ụdị ngwa dị iche iche nwere ike ime. Ngwa a nwere piperazine-1-carboxylate core, bụ nke a na-ejikarị eme ihe na kemịkalụ ọgwụ n'ihi ọdịdị ya dị iche iche na ọtụtụ ohere ịchọta ọgwụ.Ọnụnọ nke ngwongwo piperazine na-enye ohere maka mmekọrịta dị iche iche na ndị na-anabata ya na enzymes, na-eme ka ọ bụrụ onye na-adọrọ mmasị maka mmepe nke ndị na-agwọ ọrịa. 6- (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7, 8-dihydropyrido [2,3-d] pyrimidin-2-yl otu na nhazi ahụ na-enye ọrụ ọgwụ nwere ike ime.Ụdị pyrido[2,3-d] pyrimidine ndị dị otú ahụ ka a mụọla nke ọma maka ihe ndị na-egbochi mkpali, ọgwụ nje, na anticancer.Ndị otu cyclopentyl na methyl na-enye aka na lipophilicity nke ogige ahụ, nke nwere ike ịkwalite permeability cellular ya na bioavailability. Otu tert-butyl ester na-enye nkwụsi ike na ogige ahụ ma nwee ike ịtụgharị ngwa ngwa gaa na ndị ọzọ na-arụ ọrụ, na-enye ohere maka mgbanwe ndị ọzọ ma ọ bụ derivatization.Mgbanwe a bara uru na kemịkalụ ọgwụ, ebe ọ na-eme ka mmepe nke ogige ndị dị ike na nhọrọ dị iche iche. Otu pyridin-3-yl dị na nhazi ahụ na-arụ ọrụ dị ka njikọ nwere ike maka ndị na-anabata ihe dị iche iche, dị ka G protein-coupled receptors (GPCRs).Nke a na-egosi na ogige ahụ nwere ike inwe mmetụta na ụzọ mgbaàmà nke intracellular ma nwee ike nyochaa ọzọ maka ikike ya dị ka onye modulator ma ọ bụ onye na-emegide ndị na-anabata ya kpọmkwem na-etinye aka na ọnọdụ ọrịa. Nhazi zuru oke nke tert-butyl 4- (6- (6-). (1-butoxyvinyl) -8-cyclopentyl-5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate pụta ìhè. ikike ya na mmepe nke usoro ọgwụgwọ ọhụrụ.Ọ na-enye ohere iji nyochaa mgbochi enzyme, njide nnabata, na mgbanwe nke usoro ndu dị iche iche. Site n'inyocha nyocha na njikarịcha, onyinye a nwere ike ịrụ ọrụ dị ka ihe na-eduga ná mmepe nke ọgwụ ndị na-eche ọrịa cancer, mbufụt, ma ọ bụ ọrịa ndị ọzọ.Atụmatụ nhazi ya pụrụ iche na ihe omume ndị nwere ike ime ka ọ bụrụ ihe na-adọrọ mmasị maka nyocha na mmepe na ngalaba nke ọgwụ kemịkal. Na njedebe, tert-butyl 4- (6- (6- (1-butoxyvinyl)) -8-cyclopentyl- 5-methyl-7-oxo-7,8-dihydropyrido [2,3-d] pyrimidin-2-yl) amino) pyridin-3-yl) piperazine-1-carboxylate na-ekwe nkwa dị ka onyinye dị iche iche maka mmepe ọgwụ.Usoro ya dị mgbagwoju anya na ihe omume ọgwụ nwere ike ime ka ọ bụrụ onye na-adọrọ mmasị maka nyocha ọzọ dị ka onye nwere ike ịgwọ ọrịa maka ọrịa na ọnọdụ dị iche iche.