Ngwaahịa

Ebu ụzọ malite Telithromycin na Germany dị ka ọgwụgwọ ọnụ otu ugboro kwa ụbọchị maka ọrịa iku ume gụnyere oyi baa nke obodo enwetara, nnukwu nje nje na-akpa ike nke bronchitis na-adịghị ala ala, nnukwu sinusitis na tonsillitis/pharyngitis.Nke a na-emepụta semisynthetic nke macrolide erythromycin eke bụ ketolide mbụ erere, klas ọhụrụ nke ọgwụ nje na-egosipụta C3-ketone kama ịbụ otu L-cladinose.Ihe nje nje nje mgbanaka 14 nwere akụkụ na-egbochi njikọ protein nje site na ijikọ na ngalaba abụọ nke mpaghara 50S nke ribosomes nje.Ọ na-egosi ike in vitro ọrụ megide nje ndị na-eku ume na-emekarị gụnyere Streptococcus pneumoniae, Haemophilus influenzae, Moraxella catarrhalis na Streptococcus pyogenes yana ọrịa ndị ọzọ na-adịghị ahụkebe.Otu 3-keto na-enye mmụba acidic kwụsie ike na mbelata ntinye nke nguzogide macrolide-lincosamide-streptogramin B nke a na-ahụkarị na macrolides.Ihe fọdụrụnụ C11-C12 nke carbmate nọchiri anya na-egosi na ọ bụghị naanị na-eme ka mmekọrịta dị n'etiti saịtị ribosomal kamakwa iji mee ka ogige ahụ guzosie ike megide esterase hydrolysis ma zere nguzogide n'ihi mkpochapụ nke macrolides site na cell site na mgbapụta efflux nke mef gene na-etinye na ụfọdụ pathogens. .Telithromycin bụ ma ihe mgbochi asọmpi yana mkpụrụ nke CYP3A4.Otú ọ dị, n'adịghị ka ọtụtụ macrolides dị ka troleandomycin, ọ naghị emepụta ihe mgbochi CYP P-450 Fe2+-nitrosoalkane metabolite complex nke nwere ike ịkpata hepatotoxic.A na-anabata ọgwụ ahụ nke ọma ma kesaa ya nke ọma n'ime anụ ahụ pulmonary, bronchial secretions, tonsils na saliva.Ọ na-atụgharị na-etinye uche nke ukwuu na azurophil granules nke polymorphonuclear neutrophils si otú ahụ na-eme ka nnyefe ya na nje bacteria phagocytosed.