Ngwaahịa

S-(+)-Methyl-(2-chlorophenyl) [(2- (2-thienyl) amino] acetate hydrochloride, nke a makwaara dị ka S- (+) -Clopidogrel, bụ ọgwụ ọgwụ nwere usoro kemịkalụ nke C16H16ClNO2SH·HCl. Ọ bụ ihe mmepụta chiral nke clopidogrel, nke bụ ọgwụ antiplatelet dị mkpa. Ojiji mbụ nke S- (+) -Methyl- (2-chlorophenyl) [(2- (2-thienyl) amino] acetate hydrochloride bụ ihe na-arụsi ọrụ ike. Ọ na-arụ ọrụ ọgwụgwọ ya site na igbochi nchịkọta platelet, na-egbochi mkpụkọ ọbara, na ibelata ihe ize ndụ nke ọrịa obi. Ọrụ dị mkpa na ịgbalite na nchịkọta nke platelet site na ijikọ nke ọma na onye na-anabata ya, S- (+) -Methyl- (2-chlorophenyl) [(2--thienyl) amino] acetate hydrochloride na-egbochi ịgbalite platelet ma gbochie nhazi ahụ. Usoro a na-eme ka ọ bụrụ ọgwụ dị mkpa maka igbochi ihe omume thrombotic na ndị ọrịa nọ n'ihe ize ndụ dị elu, dị ka ndị nwere akụkọ ihe mere eme nke nnukwu ọrịa obi, ọrịa strok ischemic, ma ọ bụ ọrịa artery peripheral.S- (+)-Methyl- (2-chlorophenyl) [(2- (2-thienyl)amino] acetate hydrochloride na-enyekarị ọnụ n'ụdị mbadamba nkume ma ọ bụ capsules.Mgbe ọ risịrị nri, ọ na-enweta mgbanwe nke metabolic na imeju iji mepụta metabolite na-arụ ọrụ.Metabolite a na-arụ ọrụ na-ejikọta ya na onye na-anabata P2Y12, na-egosipụta mmetụta antiplatelet ya ruo ogologo oge.A na-enyekarị ogige ahụ otu ugboro kwa ụbọchị, ma ọ bụ dị ka ọgwụgwọ kwụ ọtọ ma ọ bụ yana ọgwụ antiplatelet ndị ọzọ, dị ka aspirin. Ọ dị mkpa iburu n'uche na S- (+) -Methyl- (2-chlorophenyl) -thienyl) amino] acetate hydrochloride kwesịrị iji naanị n'okpuru nduzi nke ọkachamara ahụike, n'ihi na ojiji ya nwere ike inwe ikike.