Ngwaahịa

(S)-(2-Chloro-5-iodophenyl) (4- (tetrahydrofuran-3-yloxy) phenyl) methanone, nke a makwaara dị ka CF3-112, bụ ihe mejupụtara kemịkalụ nwere ọtụtụ ngwa dị mkpa na ngalaba nke kemịkalụ ọgwụ na ọgwụ. mmepe.Otu n'ime isi ojiji nke CF3-112 bụ ihe mgbochi kinase.Kinases bụ enzymes nke na-achịkwa usoro cellular dị iche iche n'ime ahụ, gụnyere uto cell, nkewa, na nkwurịta okwu.A na-ejikọkarị dysregulation nke kinases na ọrịa dịka ọrịa kansa na ọrịa autoimmune.Achọpụtara CF3-112 ka ọ na-egosipụta ọrụ mgbochi siri ike megide ụfọdụ kinases, na-eme ka ọ bụrụ onye na-ekwe nkwa maka mmepe nke usoro ọgwụgwọ ezubere iche. Karịsịa, CF3-112 egosila ọrụ mgbochi megide Aurora kinases, nke na-arụ ọrụ dị mkpa na nkewa cell na a na-egosipụtakarị oke na mkpụrụ ndụ kansa.Site n'ichebe na igbochi kinases ndị a, CF3-112 nwere ike inye aka kwụsị ngwa ngwa nke mkpụrụ ndụ cancer ma nwee ike inye uru ọgwụgwọ. Ọzọkwa, CF3-112 egosipụtawo ọrụ megide kinases ndị ọzọ dị ka FLT3 na JAK2, bụ ndị na-etinye aka na hematological. ọrịa ndị dị ka nnukwu myeloid leukemia (AML) na myeloproliferative neoplasms.Igbochi kinases ndị a na CF3-112 nwere ikike imebi ụzọ mgbaàmà nke na-akwalite uto na nlanarị nke mkpụrụ ndụ kansa, na-enye ohere ọhụrụ maka ọgwụgwọ ọrịa ndị a. Na mgbakwunye na ọrụ inhibitory kinase, CF3-112 nwekwara ike ịnwe mgbochi. - mkpali mmetụta.Mbufụt bụ nzaghachi dị mgbagwoju anya nke ndu nke na-ekere òkè n'ọtụtụ ọrịa, gụnyere ọrịa autoimmune na ọnọdụ mkpali na-adịghị ala ala.CF3-112 egosila nkwa dị ka onye na-egbochi ụfọdụ ụzọ mkpali, nwere ike ịnye usoro ọgwụgwọ maka ijikwa ọnọdụ ndị a. Ọ bụ ezie na CF3-112 nwere ikike dị ukwuu, ọ dị mkpa iburu n'obi na nyocha na mmepe ọzọ dị mkpa iji ghọta nke ọma ịdị irè ya, nchekwa. profaịlụ, yana ngwa kacha mma.Dị ka ọ dị na ogige ọ bụla, a na-achọ nyocha siri ike na ọmụmụ ihe tupu ya enwee ike ịga n'ihu na ule ụlọ ọgwụ mmadụ. N'ikpeazụ, CF3-112 bụ ngwakọta nwere ikike dị ukwuu n'ọhịa nke ọgwụ ọgwụ.Ọrụ inhibitory kinase ya, ọkachasị megide Aurora kinases, FLT3, na JAK2, na-edobe ya dị ka onye nwere ike ime mmepe nke usoro ọgwụgwọ ezubere iche maka ọrịa kansa na ọrịa hematological.Njirimara mgbochi mkpali ya na-atụkwa aro ngwa nwere ike ijikwa ọrịa autoimmune na ọnọdụ mkpali na-adịghị ala ala.Agbanyeghị, nyocha ọzọ dị mkpa iji meghee ikike ọgwụgwọ ya zuru oke ma nyochaa nchekwa ya na nrụpụta ya.