Orlistat Cas: 96829-58-2
| Nọmba katalọgụ | XD91190 |
| Aha ngwaahịa | Orlistat |
| CAS | 96829-58-2 |
| Usoro ihe omimi | C29H53NO5 |
| Ibu molekụla | 495.73 |
| Nkọwa nchekwa | 2 ruo 8 Celsius C |
Nkọwapụta ngwaahịa
| Ọdịdị | Ọcha ntụ ntụ |
| Asay | 99% |
Ọhụụ ọhụrụ na-ebelata ibu na ọgwụ na-eweda egbugbere ọnụ: Orlistat bụ ụdị ọhụrụ mbelata ibu na ọgwụ na-eweda egbugbere ọnụ nke mba ụwa ghọtara ugbu a.N'ịre ahịa kwa afọ nke US $ 538 nde, orlistat nwere ugbu a 80% nke ahịa oke ibu zuru ụwa ọnụ, yana ire ahịa kwa afọ na Hong Kong, China naanị ruru US $ 80 nde.Ugbu a ọ bụ naanị OTC ọgwụ na-ebelata ibu n'ụwa.Ihe karịrị mmadụ 40,000,000 gburugburu ụwa ewerela ya wee felata nke ọma.Ugbu a ọ bụ ngwaahịa na-ebelata ibu arọ kacha ere.Ọ dị irè maka ọnwụ arọ.Orlistat bụ ihe na-egbochi lipase eriri afọ nke nwere ike na-eme ogologo oge.Site ozugbo igbochi ahu absorption nke abụba na nri, ozugbo oriri nke kalori na abụba bụ ihe na-erughị oriri, Isi abụba na- ndammana belata, ka nweta nzube nke arọ ọnwụ.Ọ dị mma ịkwụsị ibu, ihe ndị na-arụ ọrụ adịghị abanye n'ọbara ọbara, ma ghara ime ihe na usoro nhụjuanya nke etiti.
Orlistat bụ onye na-eme ihe na-eme ogologo oge na nke nwere ike ime ihe mgbochi lipase eriri afọ, na-acha ọcha ma ọ bụ na-acha ọcha ntụ ntụ na ọnụ ụlọ okpomọkụ, mmiri na-esighị ike na mmiri, soluble na chloroform, na-adị mfe soluble na ethanol.Saịtị serine na-arụ ọrụ nke lipase gastric na pancreatic lipase na-etolite njikọ covalent iji mebie enzymes.Abụba dị n'ime nri enweghị ike ịgbaji ka ọ bụrụ fatty acids na monoacylglycerol, yabụ enweghị ike itinye abụba ma tinye ya n'ọrụ, si otú ahụ belata oriri calorie nke anụ ahụ na ịchịkwa ibu ahụ.Ọgwụ a anaghị achọ nnabata sistemu ka ọ rụọ ọrụ.Na usoro ọgwụgwọ mbụ, enwere ike igbochi nnabata abụba site na 30%.Ọ na-adịkarịghị etinye uche ya mgbe nchịkwa ọnụ gasịrị, enwere ike ime ya site na metabolism na tract intestinal.Ebe metabolic dị na mgbidi nke eriri afọ tract, na nkwụsị ọkara ndụ bụ ihe dịka awa 14 ruo 19.Ihe dị ka 97% nke ngwaahịa a na-esi na nsị, nke 83% na-apụ n'ụdị mbụ ya.
Enwere ike iji ya na ụlọ ọgwụ na oke ibu na hyperlipidemia.N'okpuru ọnọdụ nkịtị, a na-ewere dose nke 120 mg ọnụ, ugboro atọ n'ụbọchị, na nri ma ọ bụ 1 awa mgbe nri gasịrị.Ibu nwere ike ịmalite ịdalata mgbe izu 2 gachara ọgwụ.Enwere ike iwere ya mgbe niile maka ọnwa 6 ruo 12.Ọ bụrụ na a na-abawanye dose ahụ karịa 400 mg kwa ụbọchị, mmetụta ya agaghịzi enwe nkwalite.
