Nicotinamide Riboside Cas: 1341-23-7
| Nọmba katalọgụ | XD91951 |
| Aha ngwaahịa | Nicotinamide riboside |
| CAS | 1341-23-7 |
| Ụdị molekụlala | C11H15N2O5+ |
| Ibu molekụla | 255.25 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 2933199090 |
Nkọwapụta ngwaahịa
| Ọdịdị | Ọcha ntụ ntụ |
| Asay | 99% nkeji |
Enwere ike iji Nicotinamide Riboside mee ihe n'ọmụmụ ihe ọmụmụ nke mkpụrụ ndụ ihe nketa circadian reprogramming transcriptome na imeju mara ụzọ metabolic nke ịka nká na òké.Ọ na-abawanye NAD + na cerebral cortex ma na-ebelata nhụsianya nhụsianya na ụdị òké transgenic nke ọrịa Alzheimer.
Nicotinamide adenine dinucleotide (NAD +) bụ coenzyme dị oke egwu nke, mgbe a na-ebelata ya na NADH, na-eje ozi dị ka onye na-ebelata ego inye electrons maka phosphorylation oxidative na njikọ ATP na mitochondria.NAD + bụ ihe na-enye aka dị mkpa maka enzymes dị ka sirtuins, ADP-ribosyltransferases (ARTs), na Poly [ADP-ribose] polymerases (PARPs) na enzymes ndị a na-eri ya mgbe niile.Oke NAD+/NADH bụ akụkụ dị oke mkpa nke ọnọdụ redox nke cell.(Verdin 2015).Site na ọnụ ọgụgụ ụfọdụ, NAD ma ọ bụ NADP metụtara ya na-ekere òkè na otu ụzọ n'ụzọ anọ nke mmeghachi omume cellular (Opitz Heiland 2015).Enwere akụkụ dị iche iche nke NAD + na nucleus, mitochondria, na cytoplasm (Verdin 2015).
Enwere ike ịtụgharị Nicotinamide riboside (NR) ka ọ bụrụ NAD + site na usoro etiti nke a na-atụgharị ya na nicotinamide mononucleotide (NMN) site na NR kinase (Nrk) wee banye NAD + site na NMNAT.A na-ahụ NR n'ụdị nri ụfọdụ mana ọ dị obere (dịka obere micromolar dị ala).N'akụkọ ihe mere eme, NR siri ike inweta n'ọtụtụ dị ọcha, mana ekele maka ọganihu na usoro nhazi (Yang 2007), dịka nke June 2013, a na-ere ya dị ka ihe mgbakwunye nri.
