Ngwaahịa

N-[(2'-cyano [1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride bụ ọgwụ a na-ejikarị agwọ ọbara mgbali elu, nke a makwaara dị ka ọbara mgbali elu.Ọ bụ nke otu ọgwụ a na-akpọ angiotensin-converting enzyme (ACE) inhibitors. Ọbara mgbali elu bụ ọnọdụ a na-ahụkarị nke nwere ike ịbawanye ohere nke ọtụtụ nsogbu ahụike, gụnyere ọrịa obi, ọrịa strok, na mmebi akụrụ.A na-enyekarị ndị na-egbochi ACE, dị ka N-[(2'-cyano [1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride, iji nyere aka belata ọbara mgbali elu na ibelata nsogbu na obi. arịa ọbara.Ụdị usoro ọrụ maka N-[(2'-cyano [1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride na-egbochi ọrụ nke angiotensin-converting enzyme (ACE). ).ACE na-ahụ maka ịtụgharị angiotensin I ka ọ bụrụ angiotensin II, vasoconstrictor nwere ike, nke na-ebelata arịa ọbara ma na-ebuli ọbara mgbali elu.Site na igbochi ACE, ọgwụ a na-enyere aka igbochi nhazi nke angiotensin II, na-eduga na vasodilation (ịgbasa arịa ọbara) na mbelata ọbara mgbali elu.N-[(2'-cyano [1,1'biphenyl]) -4-yl )methyl] -methyl ester L-valine monohydrochloride bụ nke a na-ejikarị ọnụ, na-emekarị ka usoro onunu ogwu otu ugboro kwa ụbọchị.Usoro ọgwụgwọ a kapịrị ọnụ na ugboro ole nchịkwa ga-adabere n'ihe dị iche iche, gụnyere oke ọbara mgbali elu na nzaghachi onye ahụ na ọgwụgwọ.Enwere ike iji ọgwụ a naanị ma ọ bụ yana yana ọgwụ ndị ọzọ antihypertensive iji nweta njikwa ọbara mgbali kacha mma. Ọ dị mkpa iburu n'uche na N-[(2'-cyano [1,1'biphenyl]-4-yl)methyl] ester L-valine monohydrochloride nwere ike ịkpata mmetụta ụfọdụ na ụfọdụ ndị mmadụ.Mmetụta ndị a na-ahụkarị gụnyere dizziness, isi ọwụwa, ụkwara akọrọ, na ike ọgwụgwụ.Ọ bụrụ na mmetụta ndị a na-adịgide ma ọ bụ na-enye nsogbu, a na-atụ aro ka ịkpọtụrụ onye ọkachamara ahụike.N'ọnọdụ ndị a na-adịghị ahụkebe, mmetụta dị njọ nwere ike ime, dị ka mmeghachi ahụ nfụkasị ahụ, nsogbu akụrụ, ma ọ bụ angioedema (oke ọzịza nke ihu, egbugbere ọnụ, akpịrị, ma ọ bụ ire).Ọ bụrụ na enwere mmetụta ọ bụla siri ike, a ga-achọ nlekọta ahụike ozugbo. Tupu ịmalite N-[(2'-cyano [1,1'biphenyl]-4-yl)methyl]-methyl ester L-valine monohydrochloride, ọ dị mkpa. iji kpughee ọnọdụ ahụike ọ bụla dị adị ma ọ bụ ihe nfụkasị ahụ na dọkịta na-ede akwụkwọ.Ọgwụ ahụ nwere ike ọ gaghị adabara ndị mmadụ nwere akụkọ ihe mere eme nke ọrịa akụrụ, ọrịa imeju, ma ọ bụ ọrịa obi, n'ihi na ọ nwere ike ime ka ọnọdụ ndị a dịkwuo njọ. Na nchịkọta, N-[(2'-cyano[1,1'biphenyl]-4) -yl)methyl]-methyl ester L-valine monohydrochloride bụ ihe mgbochi ACE eji agwọ ọbara mgbali elu.Site na igbochi ACE, ọ na-enyere aka ịgbasa arịa ọbara na iwetulata ọbara mgbali.Ịrapagidesi ike na usoro onunu ogwu, nleba anya mgbe nile na ndị ọkachamara ahụike, na nlekota maka mmetụta ndị nwere ike ime dị mkpa maka iji ọgwụ a dị mma ma dị irè.Ọ dịkwa mkpa ịnọgide na-ebi ndụ dị mma, gụnyere mmega ahụ mgbe nile, nri kwesịrị ekwesị, na nlekọta nchekasị, iji kwadokwuo njikwa ọbara mgbali.