Ngwaahịa

Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate bụ ihe mejupụtara kemịkalụ nwere ike iji mee ihe na ngwa dị iche iche, nke bụ isi na ngalaba ọgwụ. Ngwa a bụ nke Ezinụlọ nke benzimidazole, nke a na-enyocha ọtụtụ ebe maka ike ọgwụgwọ ha.Achọpụtala Benzimidazoles iji gosipụta ọtụtụ ihe omume dị ndụ, gụnyere anticancer, antifungal, antibacterial, antiviral, na mgbochi mkpali Njirimara.Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl] -2-ethoxy-1H -benzimidazole-7-carboxylate nwere ike ije ozi dị ka scaffold ma ọ bụ isi nhazi maka imewe na mmepe nke ọgwụ ọhụrụ.Usoro kemịkalụ ya pụrụ iche na-enye ohere maka ngbanwe na njikarịcha iji kwalite mmemme ọgwụ achọrọ ma ọ bụ gbado anya ụzọ ọrịa ụfọdụ.Medicinal chemists nwere ike ahu nagide a compound dị ka mmalite maka synthesizing novel ụmụ irighiri na nwere ike ọgwụgwọ ngwa.Site na-ewebata kwesịrị ekwesị kemịkalụ substituents ma ọ bụ arụ ọrụ dị iche iche na isi Ọdịdị, na-eme nnyocha nwere ike ịmepụta ihe mmepụta nke nwere mma ike, selectivity, na pharmacokinetic Njirimara.Mgbanwe ndị a nwere ike ịkwalite arụmọrụ nke ogige ahụ n'ịchụso usoro ọrịa kpọmkwem ma ọ bụ ihe mgbaru ọsọ molekụla, na-eduga na mmepe nke ọgwụ ndị dị irè karị. Enwere ike ịme nnwale na ọmụmụ ihe iji nyochaa ọrụ ndụ nke ogige ahụ site na iji nyocha nke dabeere na vitro cell ma ọ bụ na ụdị anụmanụ vivo.Nke a nwere ike inye nghọta bara uru n'ime ngwa ọgwụgwọ ya nwere ike ime ma na-eduzi njikarịcha n'ihu. Na mgbakwunye, onyinye a nwere ike ịbụ ngwá ọrụ bara uru n'ịmụ njikọ nhazi-ọrụ (SAR) nke benzimidazole.Site synthesizing analogs na ọdịiche dị n'akụkụ n'agbụ ma ọ bụ ọrụ otu, ndị ọkà mmụta sayensị nwere ike nweta a mma nghọta otú kpọmkwem structural mgbanwe emetụta compound si ọrụ na selectivity.Ihe omuma a nwere ike inye aka n'ichepụta ezi uche nke ndị na-eme ọgwụ ike na ndị na-ahọrọ ọgwụ ọjọọ. Ọzọkwa, a pụrụ iji onyinye a mee ihe na mmepe nke prodrugs, ebe a na-ahọrọ ethoxy otu, na-ahapụ ọgwụ na-arụsi ọrụ ike na saịtị ahụ.Ngwa ndị na-emepụta ihe na-enye uru dị ka mma solubility, bioavailability na-emewanyewanye, na nnyefe ọgwụ kpọmkwem nke anụ ahụ, si otú ahụ na-eme ka ọ dị irè ọgwụ ọjọọ ma na-ebelata mmetụta dị n'akụkụ. tupu atụle ogige maka mmepe ụlọ ọgwụ.Nke a dị oké mkpa iji hụ na nchekwa ya, ịdị irè ya, na adabara maka ngwa ọgwụgwọ. Na mmechi, Methyl 1-[(2'-cyanobiphenyl-4-yl)methyl]-2-ethoxy-1H-benzimidazole-7-carboxylate na-ekwe nkwa dị ka Ngwakọta dị iche iche nwere ngwa nwere ike n'ọhịa nke ọgwụ.Ọdịdị ya pụrụ iche na akụrụngwa kemịkalụ na-enye ohere maka nchọpụta ọgwụ, njikarịcha na mmepe nke prodrugs.Otú ọ dị, a chọrọ nyocha na nyocha ọzọ iji chọpụta n'ụzọ zuru ezu ike ọgwụgwọ ya ma hụ na nchekwa ya maka ojiji ụlọ ọgwụ.