Losartan CAS: 114798-26-4
Nọmba katalọgụ | XD93387 |
Aha ngwaahịa | Losartan |
CAS | 114798-26-4 |
Ụdị molekụlala | C22H23ClN6O |
Ibu molekụla | 422.91 |
Nkọwa nchekwa | Ambient |
Nkọwapụta ngwaahịa
Ọdịdị | Ọcha ntụ ntụ |
Asay | 99% nkeji |
Losartan bụ ọgwụ sitere na klaasị ọgwụ akpọrọ angiotensin II receptor blockers (ARBs).A na-ejikarị ya agwọ ọbara mgbali elu (ọbara mgbali elu) na ụfọdụ ụdị ọnọdụ obi. Ọbara mgbali elu bụ ọnọdụ a na-ahụkarị site na ọkwa ọbara mgbali elu dị elu.Ọ bụrụ na a naghị agwọ ya, ọ nwere ike bute nsogbu ahụike siri ike dịka ọrịa obi, ọrịa strok, na akụrụ.Losartan na-arụ ọrụ site n'igbochi ọrụ nke hormone a na-akpọ angiotensin II, nke na-egbochi arịa ọbara ma na-eme ka ọbara mgbali elu bilie.Site n'igbochi homonụ a, losartan na-enyere aka ịgbatị ma gbasaa arịa ọbara, si otú a na-ebelata ọbara mgbali. Na mgbakwunye na ọgwụgwọ ọbara mgbali elu, losartan na-abakwa uru maka ụfọdụ ọnọdụ obi, dị ka nkụda mmụọ obi na hypertrophy ventricular ekpe.Ọ nwere ike inye aka melite mgbaàmà, kwalite ọrụ obi, ma belata ihe ize ndụ nke ọrịa obi na ndị ọrịa nwere ọnọdụ ndị a. Ọzọkwa, a chọpụtala na losartan nwere mmetụta na-echebe akụrụ na ndị nwere ọrịa shuga 2 na ọrịa shuga nephropathy (ọrịa akụrụ).Ọ nwere ike belata ọganihu nke mmebi akụrụ, belata proteinuria (protein dị ukwuu na mmamịrị), ma nyere aka chekwaa ọrụ akụrụ n'ime ndị a. Usoro ọgwụgwọ na ojiji nke losartan nwere ike ịdịgasị iche dabere na ọnọdụ onye ahụ, afọ, na ihe ndị ọzọ.A na-aṅụkarị ya otu ugboro n'ụbọchị, yana nri ma ọ bụ na-ejighị ya.Ọ dị mkpa ịgbaso usoro onunu ogwu na ntuziaka nke ọkachamara ahụike nyere. Dị ka ọ dị na ọgwụ ọ bụla, losartan nwere ike inwe mmetụta dị n'akụkụ.Mmetụta ndị a na-ahụkarị nwere ike ịgụnye isi ọwụwa, ike ọgwụgwụ, isi ọwụwa, na iwe iwe.A na-atụ aro ka ị kọọrọ onye na-ahụ maka ahụike mmetụta ọ bụla siri ike ma ọ bụ na-adịgide adịgide. Na nchịkọta, losartan bụ ihe mgbochi angiotensin II receptor blocker nke a na-ejikarị eme ihe maka ọgwụgwọ ọbara mgbali elu, ọnọdụ obi dị ka nkụda mmụọ obi, na ọrịa shuga nephropathy.Site na igbochi ọrụ angiotensin II, losartan na-enyere aka izu ike na ịgbasa arịa ọbara, si otú a na-ebelata ọbara mgbali elu na imeziwanye ọrụ obi.Ọ bụ ọgwụ bara uru n'ịchịkwa ọnọdụ ndị a, a ga-ewerekwa ya dịka onye ọkachamara ahụike gwara ya.