Ngwaahịa

Uzo esi agwọ T2DM, ọrịa nke enwere nrụrụ abụọ nke arụ ọrụ sel islet na nguzogide insulin, gụnyere ihe na-eme ka mpụta insulin site na pancreas (ndị nzuzo), ihe ndị na-eme ka anụ ahụ dị iche iche na-emetụta insulin (ndị na-ahụ maka mmetụta), na Liraglutide, onye na-anabata GLP-1 iji rute n'ahịa, nwere 97% homology na GLP-1 na naanị amino acid abụọ na-agbanwe yana mgbakwunye nke yinye acid fatty acid.Kpọmkwem, lysine nọ n'ọnọdụ 34 ka ejiri arginine dochie ya, na lysine nọ n'ọnọdụ 26 ka ejiri C16 acyl yinye gbanwee site na glutamoyl spacer.Liraglutide na-enweta nguzogide ya na nbibi DPP-4 site na ike ya na-etolite micelles na ijikọ na albumin.N'adịghị ka exenatide bu ya ụzọ, nke na-achọ injection subcutaneous ugboro abụọ kwa ụbọchị tupu nri mbụ na nke ikpeazụ nke ụbọchị, a kwadoro liraglutide dị ka usoro ọgwụgwọ otu ugboro kwa ụbọchị ma enwere ike iji ya na metformin ma ọ bụ sulfonylurea na ndị ọrịa na-enweghị njikwa glycemic zuru oke na nke ọ bụla. monotherapy ma ọ bụ ọgwụgwọ abụọ jikọtara ọnụ.A kwadokwara ya na ọgwụgwọ abụọ nke metformin na thiazolidinedione na ndị ọrịa na-enweghị njikwa glycemic zuru oke.Liraglutide gosipụtara ike njikọ nke 61 pM (EC50 = 55 pM maka GLP-1) maka onye na-anabata GLP-1 mmadụ.