L-Tryptophan Cas: 73-22-3 99% ntụ ntụ ọcha
| Nọmba katalọgụ | XD90295 |
| Aha ngwaahịa | L-Tryptophan |
| CAS | 73-22-3 |
| Usoro ihe omimi | C11H12N2O2 |
| Ibu molekụla | 204.22518 |
| Nkọwa nchekwa | Ambient |
| Koodu tarifu akwadoro | 29339980 |
Nkọwapụta ngwaahịa
| Nyocha | 99% nkeji |
| Ọdịdị | Ọcha ntụ ntụ |
| Ọkwa | USP32 |
| Ntughari pụrụ iche | -29.4 ruo -32.8 |
| pH | 5.5 ruo 7.0 |
| Fe | <0.003% |
| Pb | <0.0015% |
| Ọnwụ na ihicha | <0.3% |
| Ihe fọdụrụ na mgbanye | 0.1% kacha |
| Cl | 0.05% kacha |
Indoleamine 2,3-dioxygenase (IDO1) na tryptophan 2,3-dioxygenase (TDO) bụ enzymes abụọ dị iche iche nke nwere nkesa anụ ahụ dị iche iche na ọrụ physiological, mana ha abụọ na-eme ka ntụgharị nke tryptophan gaa na N-formylkynurenine (NFK).A kwadoro IDO1 n'ụlọ ọgwụ dị ka ihe mgbaru ọsọ ọgwụ obere-molecule maka ọrịa cancer, ebe ọmụmụ ihe na-egosi na TDO nwere ike ịbụ ihe mgbaru ọsọ maka immunotherapy cancer na ọrịa neurodegenerative.Anyị emepụtala nyocha nyocha dị elu maka IDO1 na TDO dabere na nyocha kemịkalụ akwụkwọ akụkọ, NFK Green, nke na-emekọ kpọmkwem na NFK iji mepụta molecule fluorescent na-acha ndụ ndụ nwere ogologo ogologo mkpali nke 400 nm na ogologo ikuku nke 510 nm.Anyị na-enye ntụnyere nke mbụ n'akụkụ n'akụkụ ọnụ ọgụgụ nke ndị na-emechi ihe na-ebipụta nke IDO1 na TDO wee kpughee na preclinical IDO1 inhibitor Compound 5l na-egosi mmeghachi omume cross-reactivity na TDO, ebe a kwadoro nhọrọ nke ndị mmechi ndị ọzọ bipụtara.E gosiputara ihe dabara adaba maka nlebanya nyocha dị elu site n'inyocha ọbá akwụkwọ nke ihe kemịkalụ 87,000 n'ụdị 384- ma ọ bụ 1536.N'ikpeazụ, anyị na-egosi na a pụkwara iji nyocha ahụ tụọ ikike nke mkpụrụ ndụ iji mee ka tryptophan metabolize na iji tụọ ike cell nke IDO1 na TDO inhibitors.
