Ngwaahịa

Onye na-ebugharị EAAT2 glutamate, na-akpata> 90% nke nnabata hippocampal glutamate.Ọ bụ ezie na a na-egosipụtakarị EAAT2 na astrocytes, ∼10% nke mkpụrụ ndụ EAAT2 ka a na-ahụ na njedebe axon.N'agbanyeghị ọkwa EAAT2 dị ala na njedebe glutamatergic, mgbe a na-etinye mpekere hippocampal na ntinye uche dị ala nke d-aspartate (ihe EAAT2), ọdụ axon na-akwakọba d-aspartate ngwa ngwa dị ka astroglia.Nke a na-egosi ndakọrịta na-akọwaghị n'etiti nkesa protein EAAT2 yana ọrụ mgbasa ozi EAAT2.Otu echiche bụ na (1) heteroexchange nke mkpụrụ dị n'ime ya na mkpụrụ dị n'èzí na-adị ngwa ngwa karịa nchịkọta net na (2) njedebe na-akwado heteroexchange n'ihi nnukwu ọkwa nke glutamate dị n'ime.Agbanyeghị, amabeghị ugbu a ma heteroexchange na nnabata nwere ọnụego yiri ya ma ọ bụ dị iche.Iji lebara okwu a anya, anyị na-eji usoro emezigharị tụnyere nha nha nke usoro abụọ ahụ na oke na oke.Mwelite ụgbụ ahụ nwere mmetụta maka mgbanwe nke ike akpụkpọ ahụ ma kpalie ya site na anions ndị na-eme ka ọ dị n'èzí kwadoro ịdị adị nke anion conductance na-ejikọtaghị ọnụ.Site na iji nke ikpeazụ, anyị na-egosipụtakwa na ọnụego heteroexchange na-adaberekwa na ike akpụkpọ ahụ.Na mgbakwunye, data anyị gara n'ihu na-egosi ọnụnọ nke ntanye sodium na EAAT2.Site na itinye ihe nchoputa ohuru na ihe nlere mbu nke glutamate nke EAAT2, anyi buru amụma na ngbanwe nke voltaji nke mgbanwe na-akpata site na nchikota nke na-adabere na voltaji nke atọ Na (+).Ọzọkwa, ma nnwale anyị na ịme anwansị anyị na-atụ aro na ọnụego nnabata nke ntanetị na heteroexchange dị na EAAT2.