Ngwaahịa

BBS4 bụ otu n'ime protein dị iche iche nke ntụpọ ha na-ebute ọrịa Bardet-Biedl (BBS), ọrịa ọtụtụ usoro, na-egosipụta na oke ibu.Ejikọtala BBS4 polymorphisms na oke oke ibu na-abụghị nke syndromic.Usoro mkpụrụ ndụ oke ibu nke BBS4, yana ọrụ nke mkpụrụ ndụ BBS4 na adipocyte dị iche na ọrụ amachaghị nke ọma.Anyị na-egosi ugbu a na Bbs4 na-arụ ọrụ dị mkpa na mgbasawanye na adipogenesis: ịgbachi nkịtị nke Bbs4 na 3T3F442A preadipocytes na-ebute nkewa cell accelerated na aberrant dị iche iche, pụtara ìhè site na ọmụmụ morphologic (ìhè, nyocha na nnyefe electron microscopy), nyocha nke metabolic (nchịkọta abụba, profaịlụ fatty acid na lipolysis) na ndenye akara adipogenic transcripts (Cebpα, Pparγ, aP2, ADRP, Perilipin).N'ime adipogenesis na mgbe a na-ama ya aka na ibu abụba, Bbs4 sel ndị gbachiri nkịtị na-agbakọ nke ukwuu karịa triglycerides karịa njikwa adipocytes, n'agbanyeghị na obere (ma ka ukwuu na ọnụ ọgụgụ) ụmụ irighiri mmiri nwere profaịlụ fatty acid gbanwere.Ya mere, mkpokọta abụba ka ukwuu n'ime sel ndị gbachiri nkịtị bụ nsonaazụ nke ma ọnụọgụ adipocyte dị elu na nke dị iche iche nke na-eduga n'ịba ụba nke abụba n'otu sel.Nchọpụta anyị na-egosi na oke ibu BBS nwere ike ịbụ akụkụ ya n'ihi ọrụ BBS4 na-arụ kpọmkwem na usoro physiological na pathophysiological nke na-eme ka ọkpụkpụ adipose dị mkpa maka oke ibu.